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使用维生素D3对髋部骨折患者的预后进行调查。

Investigation of the outcome of patients with hip fractures using vitamin D3.

作者信息

Behrouzi Ahmadreza, Hejazi Hojat, Kamali Alireza, Hadi Hoseinali

机构信息

Department of Orthopedics, Arak University of Medical Sciences, Arak.

Department of Anesthesiology, Arak University of Medical Sciences, Arak Iran.

出版信息

Eur J Transl Myol. 2018 Jul 27;28(3):7372. doi: 10.4081/ejtm.2018.7372. eCollection 2018 Jul 10.

Abstract

Hip fracture is one of the important health problems of human societies. The aim of this study was to investigate the outcome of patients with this fracture using vitamin D3. This double-blind clinical trial was performed on 100 patients with hip fractures who referred to Valiasr Hospital. All specimens were evaluated for vitamin D3. Group A have had vitamin D3 in the normal range and received a dose of 50,000 vitamin D3 as blouse. Group B included individuals with hip fractures that did not have normal vitamin D3 levels. In this group, individuals received a dose of 50,000 units vitamin D3 in the form of muscular blouse, and then 50,000 units of vitamin D3 were given orally each week up to 12 weeks after surgery. After surgery, both groups were examined clinically and radiologically for ulcer and fracture healing. Moreover, mortality was checked 2 weeks after surgery and each month until healing. There was no significant difference in radiographic examination in the two groups in the term of adhesion and fracture union (P <0.05). The formation of the union in the clinical examination 4 and 8 weeks after treatment in two groups showed significant difference. The formation of union in clinical presentation 4 weeks and 8 weeks after treatment in two groups showed significant difference (P = 0.005; P = 0.036). The results showed that a group with low vitamin D, but with supplementation, had more fracture union after 4 and 8 weeks after starting treatment. Vitamin D supplementation could improve patients' condition 4 and 8 weeks after treatment.

摘要

髋部骨折是人类社会重要的健康问题之一。本研究的目的是调查使用维生素D3治疗该骨折患者的疗效。这项双盲临床试验对100例转诊至瓦利亚斯尔医院的髋部骨折患者进行。对所有样本进行维生素D3评估。A组维生素D3水平在正常范围内,接受了一次50000单位维生素D3的单次口服给药。B组包括维生素D3水平不正常的髋部骨折患者。在该组中,患者接受一次50000单位维生素D3的肌肉注射,然后在术后12周内每周口服50000单位维生素D3。术后,对两组患者进行临床和影像学检查,以观察溃疡和骨折愈合情况。此外,在术后2周及直至愈合的每个月检查死亡率。两组在粘连和骨折愈合方面的影像学检查无显著差异(P<0.05)。两组在治疗后4周和8周的临床检查中骨折愈合情况存在显著差异。两组在治疗后4周和8周的临床表现中骨折愈合情况存在显著差异(P=0.005;P=0.036)。结果表明,维生素D水平低但补充维生素D的组在开始治疗后4周和8周骨折愈合情况更好。补充维生素D可在治疗后4周和8周改善患者状况。

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