Iannotta F, Magnoli L, Visconti G, Rampinini A, Fachinetti A, Giuliani F
Chronobiologia. 1987 Jan-Mar;14(1):39-46.
The effects of 100 micrograms, i.m. of the analog ACTH 1-17 administered at 0800 and 1800 on the secretion of cortisol, aldosterone and testosterone have been studied in normal subjects: 8 male and 8 female. The group as a whole and the males had significantly greater absolute and percent increments in plasma cortisol after administration at 1800. In the females, there was only a greater percent increment in cortisol after the evening administration. The heptadecapeptide always significantly stimulated serum aldosterone, with no difference between the two times of administration. In the females, ACTH 1-17 significantly stimulated testosterone, with a more protracted secretion after the evening administration. In the males, there was always a significant testosterone decrease after the administration of the drug, with no difference between morning and evening. In conclusion, 100 micrograms i.m. of the analog ACTH 1-17 stimulates cortisol secretion more when given during the circadian nadir of plasma cortisol, but only in men. ACTH 1-17 increases testosterone in women and decreases it in men, whereas it seems to increase aldosterone secretion in both sexes.
对8名男性和8名女性正常受试者研究了在08:00和18:00肌肉注射100微克类似物促肾上腺皮质激素1 - 17对皮质醇、醛固酮和睾酮分泌的影响。总体组以及男性在18:00给药后血浆皮质醇的绝对增加值和百分比增加值显著更大。在女性中，仅在晚间给药后皮质醇的百分比增加值更大。该十七肽总是显著刺激血清醛固酮，两次给药时间之间无差异。在女性中，促肾上腺皮质激素1 - 17显著刺激睾酮，晚间给药后分泌更持久。在男性中，给药后睾酮总是显著降低，早晚之间无差异。总之，100微克肌肉注射的类似物促肾上腺皮质激素1 - 17在血浆皮质醇的昼夜最低点给药时对皮质醇分泌的刺激作用更强，但仅在男性中如此。促肾上腺皮质激素1 - 17使女性睾酮增加而使男性睾酮降低，而它似乎在两性中均增加醛固酮分泌。
