Frysz Monika, Howe Laura D, Tobias Jonathan H, Paternoster Lavinia
MRC Integrative Epidemiology Unit at the University of Bristol, University of Bristol, Bristol, UK.
Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Wellcome Open Res. 2018 Dec 14;3:90. doi: 10.12688/wellcomeopenres.14708.2. eCollection 2018.
Puberty is a time of substantial biological and psychological changes. One of the hallmarks of puberty is a rapid growth spurt, however its timing varies between individuals. The impact of pubertal timing on later health outcomes has been of interest in life course epidemiology, however its measurement can be challenging. Age at peak height velocity (aPHV) offers an objective measure of pubertal timing without having to rely on physical examination or self-report. We describe the derivation of aPHV estimates in Avon Longitudinal Study of Parents and Children (ALSPAC) offspring, using Superimposition by Translation And Rotation (SITAR) mixed effects growth curve analysis. ALSPAC is a rich source of phenotypic and genotypic data and given the importance of pubertal timing for later health outcomes, these data offer an opportunity to explore the determinants and consequences of aPHV.
青春期是生物和心理发生重大变化的时期。青春期的一个标志是快速生长突增，但其发生时间因人而异。青春期时间对后期健康结果的影响一直是生命历程流行病学关注的问题，但其测量可能具有挑战性。身高增长速度峰值年龄（aPHV）提供了一种客观的青春期时间测量方法，无需依赖体格检查或自我报告。我们描述了在阿冯父母与儿童纵向研究（ALSPAC）后代中使用平移和旋转叠加法（SITAR）混合效应生长曲线分析得出aPHV估计值的过程。ALSPAC是表型和基因型数据的丰富来源，鉴于青春期时间对后期健康结果的重要性，这些数据为探索aPHV的决定因素和后果提供了一个机会。
