Wolf M A
Encephale. 1987 Jan-Feb;13(1):13-21.
This article details how lithium affects the membrane. Lithium would counter variations in receptor sensitivity. This hypothesis has been taken up by many authors working with different models. The practical implications of such an effect remain to be defined. Also, lithium would act on the metabolism of cyclic nucleotides, principally cyclic AMP. The enzyme adenylate-cyclase, which synthesizes the nucleotide, might be one of the main targets of its therapeutic action. Between the receptors at the exterior of the membrane and the second messengers inside the cell, the mechanisms of information transfer across the membrane (or transductor system) would in turn be affected by the cation. More precisely, by interfering with the metabolism of phospholipids, essential components of this system, lithium would modify the usual functioning of the transductor. All these observations suggest a global stabilizing effect on the membrane.
本文详细阐述了锂对细胞膜的影响。锂会对抗受体敏感性的变化。这一假说已被许多使用不同模型的作者所接受。这种效应的实际意义仍有待确定。此外，锂会作用于环核苷酸的代谢，主要是环磷酸腺苷（cAMP）。合成该核苷酸的腺苷酸环化酶可能是其治疗作用的主要靶点之一。在细胞膜外部的受体与细胞内部的第二信使之间，跨膜信息传递机制（或转导系统）也会受到该阳离子的影响。更确切地说，通过干扰磷脂（该系统的重要组成部分）的代谢，锂会改变转导器的正常功能。所有这些观察结果表明锂对细胞膜具有整体稳定作用。
