Unnikumar K R, Sood P P
Environ Res. 1987 Jun;43(1):39-47. doi: 10.1016/s0013-9351(87)80055-5.
The effect of methylmercury chloride (MMC) toxicity and its antagonism by chelating agents (N-acetyl-DL-homocysteine thiolactone and 2,3-dimercaptosuccinic acid) on succinic dehydrogenase (SDH) activity of fore-, mid-, and hindbrain and trigeminal ganglia of rats is reported in this study. A dose of 10 mg MMC/kg body weight was injected subcutaneously for 2, 7, and 15 days. The chelating agents were also injected subcutaneously in two separate groups of MMC-treated animals except in group 3. In the latter case MMC was injected in two groups of rats for 7 days, and thereafter antagonists were administered daily (40 mg/kg) for 1 week. The result shows inhibition of the enzyme with MMC in all groups and its restoration by N-acetyl-DL-homocysteine thiolactone; 2,3-dimercaptosuccinic acid, however, further reduced the enzyme level. The significance of inhibition of the enzyme in relation to tissue respiration and ATP production is discussed and the capacities of antagonists in the restoration of the SDH level are also analyzed.
本研究报告了氯化甲基汞（MMC）的毒性作用及其通过螯合剂（N-乙酰-DL-高半胱氨酸硫内酯和2,3-二巯基丁二酸）的拮抗作用对大鼠前脑、中脑、后脑及三叉神经节琥珀酸脱氢酶（SDH）活性的影响。以10mg MMC/kg体重的剂量皮下注射2、7和15天。除第3组外，在另外两组MMC处理的动物中也皮下注射螯合剂。在后一种情况下，在两组大鼠中注射MMC 7天，此后每天给予拮抗剂（40mg/kg），持续1周。结果显示，所有组中MMC均抑制该酶，而N-乙酰-DL-高半胱氨酸硫内酯可使其恢复；然而，2,3-二巯基丁二酸进一步降低了酶水平。讨论了该酶抑制与组织呼吸和ATP生成的关系，并分析了拮抗剂恢复SDH水平的能力。
