Garcia J C, Chen Y H, Hsu C S
Am J Clin Pathol. 1977 Nov;68(5):543-6. doi: 10.1093/ajcp/68.5.543.
Leukemic cells from eight adult patients with acute lymphoblastic leukemia (ALL) were examined for the T-lymphocyte (T-cell) marker of sheep erythrocyte (E) receptors and for B-lymphocyte (B-cell) markers of surface immunoglobulins (SIg), complement receptors and FC receptors. Six of these patients' leukemic cells were devoid of both T- and B-cell markers, and therefore were "null" cells. The leukemic lymphoblasts of a 79-year-old patient had all B-cell markers, including monoclonal IgG K and receptors for complement and Fc. In cells from another patient (21 years old), only complement receptors were found. A review of the literature revealed that, similar to childhood ALL, adult cases of ALL were mostly of "null" cell type. All of the T-cell type was found in approximately 20% of patients. ALL of the B-cell type occurred only rarely. The latter cell type appeared to occur mainly in the middle-aged and the elderly.
对8例成年急性淋巴细胞白血病（ALL）患者的白血病细胞进行了检测，以观察其绵羊红细胞（E）受体的T淋巴细胞（T细胞）标志物以及表面免疫球蛋白（SIg）、补体受体和Fc受体的B淋巴细胞（B细胞）标志物。其中6例患者的白血病细胞缺乏T细胞和B细胞标志物，因此为“裸”细胞。一名79岁患者的白血病原始淋巴细胞具有所有B细胞标志物，包括单克隆IgG κ以及补体和Fc受体。在另一名患者（21岁）的细胞中，仅发现了补体受体。文献回顾显示，与儿童ALL相似，成人ALL病例大多为“裸”细胞类型。约20%的患者为T细胞型ALL。B细胞型ALL仅罕见发生。后一种细胞类型似乎主要发生在中年人和老年人中。
