带有T（胸腺来源）淋巴细胞标志物的急性淋巴细胞白血病细胞
Acute lymphoblastic leukemic cells with T (thymus-derived) lymphocyte markers.
作者信息
Kersey J H, Sabad A, Gajl-Peczalska K, Hallgren H M, Yunis E J, Nesbit M E
出版信息
Science. 1973 Dec 28;182(4119):1355-6. doi: 10.1126/science.182.4119.1355.
PMID:4586464
Abstract
Five of nine children with acute lymphoblastic leukemia had lymphoblasts that bound sheep erythrocytes or reacted with antiserum to thymocytes, suggesting involvement of T (thymus-derived) cells. When lymphoblasts from all patients were examined by immunofluorescence they were found to lack a marker for B (bone marrow or bursa-equivalent) cells, that is, the presence of surface immunoglobulins.
摘要
9名急性淋巴细胞白血病患儿中有5名的淋巴母细胞能结合绵羊红细胞或与抗胸腺细胞抗血清发生反应，提示有T（胸腺衍生）细胞受累。当通过免疫荧光检查所有患者的淋巴母细胞时，发现它们缺乏B（骨髓或法氏囊等同物）细胞的标志物，即表面免疫球蛋白的存在。
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