School of Life Science , Beijing Institute of Technology , Beijing 100081 , P. R. China.
Center of Super-Diamond and Advanced Films (COSDAF) & Department of Chemistry , City University of Hong Kong , 83 Tat Chee Avenue , Kowloon , Hong Kong SAR , P. R. China.
Nano Lett. 2019 Feb 13;19(2):658-665. doi: 10.1021/acs.nanolett.8b03043. Epub 2018 Oct 23.
To make nanomedicine potentially applicable in a clinical setting, several methods have been developed to synthesize pure nanodrugs (PNDs) without using any additional inert carriers. In this work, we report a novel green, low-cost, and scalable ice-template-assisted approach which shows several unique characteristics. First, the whole process only requires adding a drug solution into an ice template and subsequent melting (or freeze-drying), allowing easy industrial mass production with low capital investment. Second, the production yield is much higher than that of the traditional reprecipitation approach. The yield of Curcumin (Cur) PNDs is over two orders (∼140 times) magnitude higher than that obtained in a typical reprecipitation preparation. By adjusting simple processing parameters, PNDs with different sizes (∼20-200 nm) can be controllably obtained. Finally, the present approach can be easily applicable for a wide range of hydrophobic therapeutic drugs without any structural modification.
为了使纳米医学在临床环境中具有潜在的应用价值，已经开发了几种方法来合成不含任何额外惰性载体的纯纳米药物（PND）。在这项工作中，我们报告了一种新颖的绿色、低成本且可扩展的冰模板辅助方法，该方法具有几个独特的特点。首先，整个过程仅需要将药物溶液加入冰模板中，然后进行融化（或冷冻干燥），允许通过低资本投资轻松进行工业大规模生产。其次，产率远高于传统的再沉淀方法。姜黄素（Cur）PND 的产率比典型的再沉淀制备方法高两个数量级（约 140 倍）。通过调整简单的处理参数，可以可控地获得不同尺寸（约 20-200nm）的 PND。最后，该方法可以轻松适用于广泛的疏水性治疗药物，而无需进行任何结构修饰。
