Department of Neurology, University of Missouri School of Medicine, Columbia, Missouri, USA.
J Spinal Cord Med. 2020 Jul;43(4):556-559. doi: 10.1080/10790268.2018.1527083. Epub 2018 Oct 22.
Intravascular large B-cell lymphoma (IVLBCL) is a rare form of Non-Hodgkin lymphoma. The central nervous system, skin and hematopoietic system are the most commonly affected sites. We report a case of IVLBCL presenting as a combined conus medullaris-cauda equina syndrome. A 55-year-old Caucasian male presented with signs and symptoms of a combined conus medullaris-cauda equina syndrome confirmed by MRI and needle EMG. PET scan revealed a hyperactive focus in the adrenal gland, and biopsy showed evidence of IVLBCL. Therapy with R-CHOP resulted in improvement of weakness. A high index of suspicion and consideration of IVLBCL in the differential for patients with these isolated spinal cord symptoms and CSF findings may help initiate early and suitable therapy which has been proven to be beneficial.
血管内大 B 细胞淋巴瘤（IVLBCL）是一种罕见的非霍奇金淋巴瘤。中枢神经系统、皮肤和造血系统是最常受影响的部位。我们报告了一例表现为圆锥马尾综合征的 IVLBCL。一名 55 岁的白人男性出现圆锥马尾综合征的体征和症状，MRI 和针 EMG 证实。PET 扫描显示肾上腺有一个高活性病灶，活检显示 IVLBCL 的证据。R-CHOP 治疗导致无力改善。对于这些孤立的脊髓症状和 CSF 发现的患者，高度怀疑并考虑 IVLBCL 可能有助于早期和适当的治疗，事实证明这是有益的。
