Li Yu-Huei, Lu Chieh-Hua, Lin Fu-Huang, Su Sheng-Chiang, Liu Jhih-Syuan, Hsieh Chang-Hsun, Hung Yi-Jen, Shieh Yi-Shing, Lee Chien-Hsing
1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
2 School of Public Health, National Defense Medical Center, Taipei, Taiwan.
Metab Syndr Relat Disord. 2019 Feb;17(1):22-28. doi: 10.1089/met.2017.0143. Epub 2018 Oct 20.
Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein secreted by immune cells, endothelial cells, vascular smooth muscle cells, and adipocytes. Recent studies indicate that Gas6 and receptors of the TAM (Tyro3, Axl, and Mer) family may be involved in the pathogenesis of obesity, systemic inflammation, and insulin resistance. The aim of this study was to investigate the association between plasma Gas6 protein and the c.843 + 7G>A Gas6 polymorphism in metabolic syndrome (MetS).
Two hundred five adults (88 men and 117 women) were recruited in this study. Plasma Gas6 concentration, general, and biochemical data were measured. All subjects were genotyped for the c.843 + 7G>A Gas6 polymorphism.
Plasma Gas6 concentrations decreased in parallel with various MetS components in all groups (P = 0.017 for trend). Patients in the second and third tertiles of Gas6 level had higher high-density lipoprotein cholesterol (HDL-C) levels than those in the first tertile overall and in the female group. Plasma Gas6 levels were significantly positively correlated with HDL-C level and negatively with fasting glucose level in the female patients. The A allele and genotype AA in single nucleotide polymorphism c.843 + 7G>A were less frequent in the subjects with MetS compared to those without MetS.
Our results demonstrated a positive correlation between Gas6 protein values and HDL-C and reinforce the association with fasting glucose. In addition, the presence of c.843 + 7G>A Gas6 polymorphisms, especially the AA genotype, had an association with MetS. The potential role of the Gas6/TAM system in MetS deserves further investigation.
生长停滞特异性蛋白6（Gas6）是一种由免疫细胞、内皮细胞、血管平滑肌细胞和脂肪细胞分泌的维生素K依赖性蛋白。最近的研究表明，Gas6和TAM（Tyro3、Axl和Mer）家族受体可能参与肥胖、全身炎症和胰岛素抵抗的发病机制。本研究旨在探讨血浆Gas6蛋白与代谢综合征（MetS）中Gas6基因c.843 + 7G>A多态性之间的关联。
本研究招募了205名成年人（88名男性和117名女性）。测量血浆Gas6浓度、一般情况和生化数据。对所有受试者进行Gas6基因c.843 + 7G>A多态性的基因分型。
所有组中，血浆Gas6浓度均与各种MetS组分呈平行下降（趋势P = 0.017）。Gas6水平处于第二和第三三分位数的患者，总体及女性组的高密度脂蛋白胆固醇（HDL-C）水平均高于第一三分位数的患者。女性患者中，血浆Gas6水平与HDL-C水平呈显著正相关，与空腹血糖水平呈负相关。与无MetS的受试者相比，MetS受试者中，单核苷酸多态性c.843 + 7G>A中的A等位基因和AA基因型频率较低。
我们的结果表明Gas6蛋白值与HDL-C之间存在正相关，并加强了与空腹血糖的关联。此外，Gas6基因c.843 + 7G>A多态性的存在，尤其是AA基因型，与MetS有关。Gas6/TAM系统在MetS中的潜在作用值得进一步研究。
