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沙门氏菌肠亚种的菌毛和相关受体。

Fimbriae and related receptors for Salmonella Enteritidis.

机构信息

College of Veterinary Medicine (Institute of Comparative Medicine), Yangzhou University, Yangzhou 225009, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China.

Jiangsu Institute of Poultry Science, Yangzhou 225125, China.

出版信息

Microb Pathog. 2019 Jan;126:357-362. doi: 10.1016/j.micpath.2018.10.025. Epub 2018 Oct 19.

Abstract

Infection with Salmonella Enteritidis (SE) is one of the main causes for food- and water-borne diseases, and is a major concern to public health for both humans and animals worldwide. Some fimbrial antigens expressed by SE strains have been described and characterized, containing SEF14, SEF17, SEF21, long polar fimbriae and plasmid-encoded fimbriae, they play a role in bacterial survival in the host or external environment. However, their functions remain to be well elucidated, with the initial attachment and binding for fimbriae-mediated SE infections only minimally understood. Meanwhile, host-pathogen interactions provide insights into receptor modulation of the host innate immune system. Therefore, to well understand the pathogenicity of SE bacteria and to comprehend the host response to infection, the host cell-SE interactions need to be characterized. This review describes SE fimbriae receptors with an emphasis on the interaction between the receptor and SE fimbriae.

摘要

感染肠炎沙门氏菌(SE)是食源性和水源性疾病的主要原因之一,也是全球人类和动物公共卫生的主要关注点。已经描述和表征了一些由 SE 菌株表达的菌毛抗原,包括 SEF14、SEF17、SEF21、长极性菌毛和质粒编码的菌毛,它们在细菌在宿主或外部环境中的存活中发挥作用。然而,它们的功能仍有待充分阐明,对于菌毛介导的 SE 感染的初始附着和结合的理解还很有限。同时,宿主-病原体相互作用为宿主先天免疫系统的受体调节提供了深入的了解。因此,为了充分了解 SE 细菌的致病性,并理解宿主对感染的反应,需要对宿主细胞-SE 相互作用进行表征。本综述描述了 SE 菌毛受体,重点介绍了受体与 SE 菌毛之间的相互作用。

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