Ohashi M, Fujio N, Kato K, Nawata H, Ibayashi H
Gerontology. 1986;32(6):335-9. doi: 10.1159/000212812.
The effects of ovine corticotropin releasing factor (o-CRF) on the secretions of ACTH, cortisol, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) were studied in the healthy young and elderly male individuals. o-CRF caused significant elevations of plasma ACTH, cortisol and DHEA concentrations, in all subjects. Moreover, there were no significant differences in the time-dependent responses of plasma ACTH, cortisol and DHEA to o-CRF between the young and elderly male individuals. o-CRF showed no significant rise of plasma DHEA-S, in all subjects. We conclude that the pituitary-adrenal sensitivity to the hypothalamic CRF in the elderly does not change with aging.
研究了羊促肾上腺皮质激素释放因子（o-CRF）对健康青年和老年男性个体促肾上腺皮质激素（ACTH）、皮质醇、脱氢表雄酮（DHEA）和硫酸脱氢表雄酮（DHEA-S）分泌的影响。在所有受试者中，o-CRF导致血浆ACTH、皮质醇和DHEA浓度显著升高。此外，青年和老年男性个体血浆ACTH、皮质醇和DHEA对o-CRF的时间依赖性反应无显著差异。在所有受试者中，o-CRF未显示血浆DHEA-S有显著升高。我们得出结论，老年人垂体-肾上腺对下丘脑CRF的敏感性不会随年龄增长而改变。
