Shealy C N
Shealy Institute, Springfield, MO 65803, USA.
Integr Physiol Behav Sci. 1995 Sep-Dec;30(4):308-13. doi: 10.1007/BF02691603.
Dehydroepiandrosterone (DHEA) is quantitatively the most abundant hormone in humans and mammals, with a wide variety of physiological effects, including major regulatory effects upon the immune system. Two of the most striking aspects of DHEA are a steady decline in DHEA with age and a significant deficiency in DHEA in patients with several major diseases, including cancer, atherosclerosis, and Alzheimer's disease. The hormone is secreted in a non-sulfated (DHEA) and sulfated form (DHEA-S). The two are apparently interchangeable, and it appears likely that its physiological effects are achieved by derivative molecules that have yet to be identified.
脱氢表雄酮（DHEA）在人类和哺乳动物体内是含量最为丰富的激素，具有广泛的生理作用，包括对免疫系统的主要调节作用。DHEA最显著的两个方面是其含量会随着年龄增长而稳步下降，以及在包括癌症、动脉粥样硬化和阿尔茨海默病在内的几种主要疾病患者中存在显著缺乏的情况。该激素以非硫酸化形式（DHEA）和硫酸化形式（DHEA-S）分泌。这两种形式显然可以相互转换，其生理作用似乎是通过尚未确定的衍生分子来实现的。
