抗真菌 4-羟基 pleurogrisein 和抗微生物 pleurotin 衍生物从线虫性担子菌的培养物。
Antiviral 4-Hydroxypleurogrisein and Antimicrobial Pleurotin Derivatives from Cultures of the Nematophagous Basidiomycete .
机构信息
Department of Microbial Drugs, Helmholtz Centre for Infection Research GmbH, Inhoffenstraße 7, 38124 Braunschweig, Germany.
German Centre for Infection Research (DZIF), partner site Hannover-Braunschweig, 38124 Braunschweig, Germany.
出版信息
Molecules. 2018 Oct 19;23(10):2697. doi: 10.3390/molecules23102697.
4-Hydroxypleurogrisein, a congener of the anticancer-lead compound pleurotin, as well as six further derivatives were isolated from the basidiomycete , strain MFLUCC 12-0451. The structures were elucidated utilizing high resolution electron spray ionization mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR) spectral data and evaluated for their biological activities; for leucopleurotin, we provide Xray data. While most congeners showed moderate antimicrobial and cytotoxic activity, 4-hydroxypleurogrisein emerged as an inhibitor of hepatitis C virus infectivity in mammalian liver cells.
4-羟基 pleurogrisein 是抗癌先导化合物 pleurotin 的同系物，以及另外六种进一步的衍生物，从担子菌 MFLUCC 12-0451 中分离出来。利用高分辨电子喷雾电离质谱（HRESIMS）和 1D 和 2D 核磁共振（NMR）谱数据阐明了这些结构，并评估了它们的生物活性；对于亮pleurotin，我们提供了 X 射线数据。虽然大多数同系物表现出中等的抗菌和细胞毒性活性，但 4-羟基 pleurogrisein 成为了哺乳动物肝细胞中丙型肝炎病毒感染的抑制剂。
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