Sułkowska-Ziaja Katarzyna, Trepa Monika, Olechowska-Jarząb Aldona, Nowak Paweł, Ziaja Marek, Kała Katarzyna, Muszyńska Bożena
Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9 Street, 30-688 Kraków, Poland.
Pharmaceuticals (Basel). 2023 Aug 23;16(9):1200. doi: 10.3390/ph16091200.
The phenomenon of drug resistance in micro-organisms necessitates the search for new compounds capable of combating them. Fungi emerge as a promising source of such compounds as they produce a wide range of secondary metabolites with bacteriostatic or fungistatic activity. These compounds can serve as alternatives for commonly used antibiotics. Furthermore, fungi also accumulate compounds with antiviral activity. This review focuses on filamentous fungi and macrofungi as sources of antimicrobial compounds. The article describes both individual isolated compounds and extracts that exhibit antibacterial, antifungal, and antiviral activity. These compounds are produced by the fruiting bodies and mycelium, as well as the biomass of mycelial cultures. Additionally, this review characterizes the chemical compounds extracted from mushrooms used in the realm of cosmetology; specifically, their antimicrobial activity.
微生物中的耐药现象使得有必要寻找能够对抗它们的新化合物。真菌作为这类化合物的一个有前景的来源而出现,因为它们产生多种具有抑菌或抑真菌活性的次生代谢产物。这些化合物可以作为常用抗生素的替代品。此外,真菌还积累具有抗病毒活性的化合物。本综述聚焦于丝状真菌和大型真菌作为抗菌化合物的来源。文章描述了具有抗菌、抗真菌和抗病毒活性的单个分离化合物以及提取物。这些化合物由子实体、菌丝体以及菌丝体培养物的生物质产生。此外,本综述还对从用于美容领域的蘑菇中提取的化合物进行了表征;具体而言,是它们的抗菌活性。