He Dong-Mei, Lai Chang Jiang-Sheng, Yan Zhu-Yun, Huang Lu-Qi
State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Center for Post-doctoral Research, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi. 2018 Sep;43(17):3417-3430. doi: 10.19540/j.cnki.cjcmm.20180510.006.
In the long-term evolution, microbes and hosts coexist widely, forming a symbiotic microecosystem and resulting the complex interactions of the metabolism. With the application of microecological theory in Chinese materia medica science, two main points have been accepted gradually. On the one hand, the prevention and treatment of human diseases by traditional Chinese medicines can be achieved through the correction and adjustment of the imbalance of the human microecosystem. On the other hand, the microecosystem can regulate the quality of traditional Chinese medicines in real time, and further affect their curative effect. Thus, a new discipline, Traditional Chinese Medical Microecology, has been gradually established. In this review, the background, theoretical structure, research directions, key problems and the relationship with human microecology of Traditional Chinese Medical Microecology were systematically summarized and prospected for promoting its development. Moreover, this review provides a reference protocol for further discoursing the microecological mechanism involving the efficacy of traditional Chinese medicines.
在长期进化过程中，微生物与宿主广泛共存，形成共生微生态系统并导致新陈代谢的复杂相互作用。随着微生态理论在中医药学中的应用，两个主要观点逐渐被接受。一方面，中药对人类疾病的防治可通过纠正和调整人体微生态系统的失衡来实现。另一方面，微生态系统可实时调节中药质量，进而影响其疗效。由此，一门新学科——中医微生态学逐渐建立起来。在这篇综述中，系统总结并展望了中医微生态学的背景、理论结构、研究方向、关键问题以及与人类微生态学的关系，以促进其发展。此外，本综述为进一步探讨涉及中药疗效的微生态机制提供了参考方案。
