Engström W, Hopkins B, Schofield P
Int J Androl. 1987 Feb;10(1):79-84. doi: 10.1111/j.1365-2605.1987.tb00168.x.
Seven testicular tumours of different histological type--two seminomas, two teratomas/teratocarcinomas/embryonal carcinomas, one mixed seminoma/teratoma, one Leydig cell tumour and one testicular lymphoma--were examined for the expression of four potentially growth regulatory genes by Northern blotting. Seven out of seven testicular tumours contained transcripts that hybridized with a human insulin cDNA-probe whereas only four out of seven tumours contained IGF II transcripts. One tumour contained high levels of LDL-receptor transcript whereas all seven tumours contained significant quantities of HMG-CoA-reductase mRNA.
对七种不同组织学类型的睾丸肿瘤——两例精原细胞瘤、两例畸胎瘤/畸胎癌/胚胎癌、一例精原细胞瘤/畸胎瘤混合型、一例莱迪希细胞瘤和一例睾丸淋巴瘤——进行了Northern印迹法检测，以分析四个潜在生长调节基因的表达情况。七例睾丸肿瘤均含有与人胰岛素cDNA探针杂交的转录本，而七例肿瘤中只有四例含有IGF II转录本。一例肿瘤含有高水平的低密度脂蛋白受体转录本，而所有七例肿瘤均含有大量的HMG-CoA还原酶mRNA。
