人类血小板中的丙咪嗪受体：年龄的影响。

Imipramine receptors in human platelets: effect of age.

作者信息

Marazziti D, Giusti P, Rotondo A, Placidi G F, Pacifici G M

出版信息

Int J Clin Pharmacol Res. 1987;7(2):145-8.

Abstract

Imipramine receptors were studied in platelets from six healthy young subjects (age between 24 and 38 years), five newborns, and six healthy elderly persons (age between 70 and 81 years). Binding parameters, the maximum binding capacity (Bmax) and the apparent dissociation constant (Kd), were determined by Scatchard's analysis. Level of differences between young subjects and the other groups was determined by Student's t-test. Bmax (mean +/- SD) was 1162 +/- 138 (young persons), 564 +/- 65 (newborn), and 508 +/- 98 (elderly persons) fmol/mg protein. The figure for the young was different from that of the newborn (p less than 0.001) and the elderly (p less than 0.01). Kd (means +/- SD) was 1.78 +/- .69 (young persons), 0.68 +/- 0.13 (newborn), and 0.80 +/- 0.27 nM in the elderly. Kd in the volunteers was different from that in the newborn or the elderly subjects (p less than 0.01). Imipramine receptors in platelets appear to be influenced by development and aging.

摘要

对6名健康年轻受试者（年龄在24至38岁之间）、5名新生儿和6名健康老年人（年龄在70至81岁之间）的血小板中的丙咪嗪受体进行了研究。通过Scatchard分析确定结合参数，即最大结合容量（Bmax）和表观解离常数（Kd）。采用学生t检验确定年轻受试者与其他组之间的差异水平。Bmax（平均值±标准差）在年轻人中为1162±138、新生儿中为564±65、老年人中为508±98 fmol/mg蛋白质。年轻人的数值与新生儿（p＜0.001）和老年人（p＜0.01）的数值不同。Kd（平均值±标准差）在年轻人中为1.78±0.69、新生儿中为0.68±0.13、老年人中为0.80±0.27 nM。志愿者中的Kd与新生儿或老年受试者中的Kd不同（p＜0.01）。血小板中的丙咪嗪受体似乎受发育和衰老的影响。