Anson Eric, Thompson Elizabeth, Karpen Samuel C, Odle Brian L, Seier Edith, Jeka John, Panus Peter C
Department of Otolaryngology, University of Rochester, 601 Elmwood Avenue, Box 629, Rochester, NY, 14642, USA.
Department of Physical Therapy, Temple University, 1800 N Broad St, Philadelphia, PA, 91222, USA.
BMC Res Notes. 2018 Oct 22;11(1):750. doi: 10.1186/s13104-018-3859-7.
Drugs increase fall risk and decrease performance on balance and mobility tests. Conversely, whether biofeedback training to reduce fall risk also decreases scores on a published drug-based fall risk index has not been documented. Forty-eight community-dwelling older adults underwent either treadmill gait training plus visual feedback (+VFB), or walked on a treadmill without feedback. The Quantitative Drug Index (QDI) was derived from each participant's drug list and is based upon all cause drug-associated fall risk. Analysis of covariance assessed changes in the QDI during the study, and data is presented as mean ± standard error of the mean.
The QDI scores decreased significantly (p = 0.031) for participants receiving treadmill gait training +VFB (- 0.259 ± 0.207), compared to participants who walked on the treadmill without VFB (0.463 ± 0.246). Changes in participants QDI scores were dependent in part upon their age, which was a significant covariate (p = 0.007). These preliminary results demonstrate that rehabilitation to reduce fall risk may also decrease use of drugs associated with falls. Determination of which drugs or drug classes that contribute to the reduction in QDI scores for participants receiving treadmill gait training +VFB, compared to treadmill walking only, will require a larger participant investigation. Trial Registration ISRNCT01690611, ClinicalTrials.gov #366151-1, initial 9/24/2012, completed 4/21/2016.
药物会增加跌倒风险,并降低平衡和运动测试的表现。相反,尚无文献记载通过生物反馈训练降低跌倒风险是否也会降低已发表的基于药物的跌倒风险指数得分。48名社区居住的老年人接受了跑步机步态训练加视觉反馈(+VFB),或在无反馈的情况下在跑步机上行走。定量药物指数(QDI)源自每位参与者的药物清单,基于所有与药物相关的全因跌倒风险。协方差分析评估了研究期间QDI的变化,数据以均值±均值标准误表示。
与在无VFB的跑步机上行走的参与者(0.463±0.246)相比,接受跑步机步态训练+VFB的参与者(-0.259±0.207)的QDI得分显著降低(p = 0.031)。参与者QDI得分的变化部分取决于他们的年龄,年龄是一个显著的协变量(p = 0.007)。这些初步结果表明,降低跌倒风险的康复训练也可能减少与跌倒相关的药物使用。与仅在跑步机上行走相比,确定哪些药物或药物类别导致接受跑步机步态训练+VFB的参与者QDI得分降低,将需要更大规模的参与者调查。试验注册ISRNCT01690611,ClinicalTrials.gov #366151-1,初始日期2012年9月日,完成日期2016年4月21日。