MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Biomed J. 2018 Aug;41(4):218-233. doi: 10.1016/j.bj.2018.08.004. Epub 2018 Sep 10.
The respiratory epithelium is the major interface between the environment and the host. Sophisticated barrier, sensing, anti-microbial and immune regulatory mechanisms have evolved to help maintain homeostasis and to defend the lung against foreign substances and pathogens. During influenza virus infection, these specialised structural cells and populations of resident immune cells come together to mount the first response to the virus, one which would play a significant role in the immediate and long term outcome of the infection. In this review, we focus on the immune defence machinery of the respiratory epithelium and briefly explore how it repairs and regenerates after infection.
呼吸道上皮是环境与宿主之间的主要界面。为了帮助维持体内平衡并防止肺部受到异物和病原体的侵害，已经进化出了复杂的屏障、感应、抗菌和免疫调节机制。在流感病毒感染期间，这些特化的结构细胞和常驻免疫细胞群共同发起对病毒的最初反应，这种反应将在感染的即时和长期结果中发挥重要作用。在这篇综述中，我们重点介绍呼吸道上皮的免疫防御机制，并简要探讨其在感染后的修复和再生方式。
