Brihaye C, Guillaume M, O'Brien H A, Raets D, de Landsheere C, Rigo P
Int J Rad Appl Instrum A. 1987;38(3):213-7. doi: 10.1016/0883-2889(87)90090-6.
Hydrous tin(IV) dioxide in the Na+-form appears to be the most efficient inorganic exchanger for a reliable and versatile clinical 82Rb generator. Continuous elution with a commercial physiological NaCl solution yields 82Rb ranging between 10 and 40% at a flow rate as low as 3 to 10 mL/min respectively. At the same time the Sr breakthrough is less than 1.6 10(-6)%/mL. A clinical generator loaded with 100 mCi 82Sr (150 mCi 85Sr) and continuously eluted for 3 min at a typical flow rate of 5 mL/min yields 40 mCi of 82Rb, 8 nCi of 82Sr and 11 nCi of 85Sr. The total absorbed radiation dose for 40 mCi 82Rb administered is primarily due to 82Rb and has been estimated for the three principal target organs as 760 mrad for the kidneys, 520 mrad for the heartwalls and 276 mrad for the lungs. The 82,85Sr contribution to the dosimetry has been shown to be negligible. The absence of radiolysis with generators loaded with high level of 82Sr was demonstrated by the excellent reproductibility of continuous elution properties of the generator during its practical shelf-life estimated to 5-6 weeks of clinical use which would require more than 30 L of eluent.
钠型水合二氧化锡似乎是用于可靠且通用的临床82Rb发生器的最有效的无机交换剂。用市售生理NaCl溶液连续洗脱，分别以低至3至10 mL/min的流速产生10%至40%的82Rb。同时，锶的穿透率小于1.6×10(-6)%/mL。一个装有100 mCi 82Sr（150 mCi 85Sr）的临床发生器，以5 mL/min的典型流速连续洗脱3分钟，可产生40 mCi的82Rb、8 nCi的82Sr和11 nCi的85Sr。给予40 mCi 82Rb的总吸收辐射剂量主要归因于82Rb，据估计，三个主要靶器官的剂量分别为：肾脏760 mrad、心壁520 mrad、肺276 mrad。已证明82、85Sr对剂量测定的贡献可忽略不计。在估计为5至6周临床使用期（这需要超过30 L洗脱液）的实际保质期内，发生器连续洗脱特性具有出色的可重复性，这证明了装有高含量82Sr的发生器不存在辐射分解。
