用于正电子发射断层扫描的心肌灌注显像的锶-82/铷-82发生器的制造及氯化铷-82的质量控制（针对患者）

Manufacture of strontium-82/rubidium-82 generators and quality control of rubidium-82 chloride for myocardial perfusion imaging in patients using positron emission tomography.

作者信息

Alvarez-Diez T M, deKemp R, Beanlands R, Vincent J

机构信息

Nuclear Medicine Division, Ottawa Civic Hospital, Ont., Canada.

出版信息

Appl Radiat Isot. 1999 Jun;50(6):1015-23. doi: 10.1016/s0969-8043(98)00170-5.

DOI:10.1016/s0969-8043(98)00170-5

PMID:10355104

Abstract

We describe a protocol to manufacture 82Sr/82Rb generators and 82RbCl for myocardial imaging with PET. The generators are manufactured in 3 stages: (1) preparation of a tin oxide column, (2) leak test of the generator column and (3) loading of the generator with 82Sr. The generators produced sterile and non-pyrogenic 82RbCl for i.v. injection. No significant 82Sr/85Sr breakthroughs were observed after elution with 20 1 of saline. The automated system delivered human doses of 82RbCl accurately.

摘要

我们描述了一种用于制造用于正电子发射断层扫描（PET）心肌成像的82Sr/82Rb发生器和82RbCl的方案。发生器分三个阶段制造：（1）氧化锡柱的制备，（2）发生器柱的泄漏测试，以及（3）用82Sr加载发生器。所生产的发生器能产生用于静脉注射的无菌、无热原的82RbCl。用20升盐水洗脱后，未观察到明显的82Sr/85Sr突破。自动化系统准确地提供了人体剂量的82RbCl。