Németh Balázs, Kiss István, Ajtay Bella, Péter Iván, Kreska Zita, Cziráki Attila, Horváth Iván G, Ajtay Zénó
Department of Public Health Medicine, Medical School, University of Pécs, Pécs, Hungary
Zsigmondy Vilmos SPA Hospital, Harkány, Hungary.
In Vivo. 2018 Nov-Dec;32(6):1555-1559. doi: 10.21873/invivo.11414.
We aimed to investigate the effects of a single carbon dioxide (CO) treatment on arterial stiffness by monitoring the changes of aortic pulse-wave velocity (PWV) and aortic augmentation index (AIXao), which are indicators of arterial stiffness.
PWV and AIXao were measured by an invasively validated oscillometric device. The measurements of stiffness parameters were performed before the CO treatment, and at 1, 4 and 8 h after the first treatment.
Thirty-one patients were included. No significant changes were found in PWV. AIXao decreased significantly 1 h and 4 h after CO treatment compared to baseline values (p=0.034 and p<0.001). AIXao increased 8 h after the CO treatment, but remained significantly lower than baseline AIXao values (p=0.016).
CO treatment is capable of reducing peripheral vascular resistance. We hypothesize that CO is not only a temporal vasodilator but is also capable of activating vasodilation pathways.
我们旨在通过监测主动脉脉搏波速度（PWV）和主动脉增强指数（AIXao）的变化来研究单次二氧化碳（CO）治疗对动脉僵硬度的影响，这两个指标是动脉僵硬度的指标。
PWV和AIXao通过经侵入性验证的示波装置进行测量。在CO治疗前以及首次治疗后1、4和8小时进行僵硬度参数的测量。
纳入31例患者。PWV未发现显著变化。与基线值相比，CO治疗后1小时和4小时AIXao显著降低（p = 0.034和p < 0.001）。CO治疗后8小时AIXao升高，但仍显著低于基线AIXao值（p = 0.016）。
CO治疗能够降低外周血管阻力。我们推测CO不仅是一种短效血管扩张剂，还能够激活血管舒张途径。
