Atalan Nazan, Acar Leyla, Yapici Nihan, Kudsioglu Turkan, Ergen Arzu, Yilmaz Seda Gulec, Isbir Turgay
Department of Anesthesiology, Marmara University Vocational School of Health Services, Istanbul, Turkey
Department of Molecular Medicine, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
In Vivo. 2018 Nov-Dec;32(6):1653-1658. doi: 10.21873/invivo.11428.
BACKGROUND/AIM: Our aim was to determine serum TLR-9 levels in sepsis and evaluate the relationship between sepsis and serum TLR-9 levels.
The study group consisted of 80 consecutive patients with sepsis and 100 healthy individuals. The demographic characteristics, co-morbidities and hemodynamic data of all patients were recorded.
TLR-9 serum levels in sepsis were statistically significantly lower compared to the control group. It was also seen that when the lactate level was >5 mmol/l in patients in the sepsis group, the serum TLR-9 levels were substantially higher.
There is a relationship between sepsis-induced immunosuppression and serum TLR-9 levels. The host immunity system can be activated by means of TLR-9-related systems, while hyperlactatemia may play a stimulating role in the re-activation of the immune system.
背景/目的：我们的目的是测定脓毒症患者血清中TLR-9水平，并评估脓毒症与血清TLR-9水平之间的关系。
研究组包括80例连续的脓毒症患者和100名健康个体。记录所有患者的人口统计学特征、合并症和血流动力学数据。
脓毒症患者的TLR-9血清水平与对照组相比有统计学显著降低。还发现，脓毒症组患者乳酸水平>5 mmol/l时，血清TLR-9水平显著更高。
脓毒症诱导的免疫抑制与血清TLR-9水平之间存在关联。宿主免疫系统可通过TLR-9相关系统被激活，而高乳酸血症可能在免疫系统的重新激活中起刺激作用。
