Department of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Tuebingen, Germany.
Department of Psychology, University of Tuebingen, Tuebingen, Germany.
Sci Rep. 2018 Oct 22;8(1):15588. doi: 10.1038/s41598-018-33777-1.
Rumination is a perseverative thinking style that is associated with adverse mental and physical health. Stressful situations have been considered as a trigger for this kind of thinking. Until today, there are mixed findings with respect to the relations of functional connectivity (FC) and rumination. The study at hand aimed to investigate, in how far high and low ruminators would show elevated levels of state rumination after a stress induction and if these changes would show corresponding changes in FC in the cognitive control network (CCN) and dorsal attention network (DAN). 23 high and 22 low trait ruminators underwent resting-state measurements before and after a stress induction with the Trier Social Stress Test (TSST). Changes in rsFC through the TSST were measured with functional near-infrared spectroscopy within and between regions of the CCN. Stress successfully induced state rumination in both groups but stronger in the high trait ruminators. High trait ruminators showed elevated FC within the CCN at baseline, but attenuated increase in FC following the TSST. Increases in FC correlated negatively with state rumination. A lack of FC reactivity within the CCN in high ruminators might reflect reduced network integration between brain regions necessary for emotion regulation and cognitive control.
反刍是一种持续的思维方式，与不良的身心健康有关。有压力的情况被认为是这种思维的触发因素。直到今天，关于功能连接（FC）和反刍之间的关系，研究结果仍存在差异。本研究旨在探讨高、低特质反刍者在应激诱导后是否会表现出更高水平的状态反刍，以及这些变化是否会在认知控制网络（CCN）和背侧注意网络（DAN）的 FC 中表现出相应的变化。23 名高特质反刍者和 22 名低特质反刍者在经过 Trier 社会应激测试（TSST）前后进行了静息状态测量。通过功能近红外光谱在 CCN 内和之间的区域测量了通过 TSST 的 rsFC 变化。应激成功地诱导了两组的状态反刍，但高特质反刍者的反应更强。高特质反刍者在基线时 CCN 内的 FC 升高，但在 TSST 后 FC 增加减弱。FC 的增加与状态反刍呈负相关。高反刍者 CCN 内 FC 反应不足可能反映了情绪调节和认知控制所需的大脑区域之间的网络整合减少。
