DePinho R, Mitsock L, Hatton K, Ferrier P, Zimmerman K, Legouy E, Tesfaye A, Collum R, Yancopoulos G, Nisen P
J Cell Biochem. 1987 Apr;33(4):257-66. doi: 10.1002/jcb.240330404.
The myc family of cellular oncogenes contains three well-defined members: c-myc, N-myc and L-myc. Additional structural and functional evidence now suggests that other myc-family oncogenes exist. The overall structure and organization of the c-, N-, and L-myc genes and transcripts are very similar. Each gene contains three exons: encoding a long 5' untranslated leader and a long 3' untranslated region. The proteins encoded by these myc genes share several stretches of significant homology. The conservation of sequences at the carboxyterminus of the L-myc protein suggests that it is also a DNA-binding, nuclear-associated protein. Each myc gene will cooperate with an activated Ha-ras oncogene to cause transformation of primary rat embryo fibroblasts. Characteristics of several new myc-family members are described.
细胞癌基因的myc家族包含三个明确的成员：c-myc、N-myc和L-myc。现在，更多的结构和功能证据表明，还存在其他myc家族癌基因。c-myc、N-myc和L-myc基因及转录本的整体结构和组织非常相似。每个基因都包含三个外显子：编码一个长的5'非翻译前导序列和一个长的3'非翻译区。这些myc基因编码的蛋白质具有几段显著的同源序列。L-myc蛋白羧基末端序列的保守性表明它也是一种与DNA结合的核相关蛋白。每个myc基因都能与激活的Ha-ras癌基因协同作用，导致原代大鼠胚胎成纤维细胞发生转化。本文描述了几个新的myc家族成员的特征。
