长链非编码RNA作为“MYC促进因子”。
Long Non-Coding RNAs as "MYC Facilitators".
作者信息
García-Caballero Daniel, Hart Jonathan R, Vogt Peter K
机构信息
Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
Pathophysiology. 2023 Sep 1;30(3):389-399. doi: 10.3390/pathophysiology30030030.
In this article, we discuss a class of MYC-interacting lncRNAs (long non-coding RNAs) that share the following criteria: They are direct transcriptional targets of MYC. Their expression is coordinated with the expression of MYC. They are required for sustained MYC-driven cell proliferation, and they are not essential for cell survival. We refer to these lncRNAs as "MYC facilitators" and discuss two representative members of this class of lncRNAs, SNHG17 (small nuclear RNA host gene) and LNROP (long non-coding regulator of POU2F2). We also present a general hypothesis on the role of lncRNAs in MYC-mediated transcriptional regulation.
在本文中，我们讨论了一类与MYC相互作用的长链非编码RNA（lncRNA），它们具有以下共同特征：它们是MYC的直接转录靶点。它们的表达与MYC的表达相互协调。它们是MYC驱动的细胞持续增殖所必需的，且对细胞存活并非至关重要。我们将这些lncRNA称为“MYC促进因子”，并讨论了这类lncRNA中的两个代表性成员，即SNHG17（小核RNA宿主基因）和LNROP（POU2F2的长链非编码调节因子）。我们还提出了一个关于lncRNA在MYC介导的转录调控中作用的一般假说。
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