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多发性骨髓瘤同时累及皮肤和中枢神经系统

Multiple myeloma with simultaneous cutaneous and central nervous system involvement.

作者信息

Nguyen James, Hassoun Hani

机构信息

Memorial Sloan-Kettering Cancer Center New York NY USA.

出版信息

Clin Case Rep. 2018 Sep 5;6(10):2015-2016. doi: 10.1002/ccr3.1626. eCollection 2018 Oct.

DOI:10.1002/ccr3.1626
PMID:30349719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6186883/
Abstract

Cutaneous involvement in multiple myeloma is an extremely rare occurrence that is underrecognized and akin CNS involvement, typically occurs late in the disease course, and is associated with an aggressive biology. Pathologic examination is key to the diagnosis and a standard of care treatment has not been established for these patients.

摘要

多发性骨髓瘤的皮肤受累极为罕见,未得到充分认识,与中枢神经系统受累相似,通常发生在疾病进程的晚期,且与侵袭性生物学行为相关。病理检查是诊断的关键,目前尚未为这些患者确立标准的治疗方案。

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本文引用的文献

1
Myelomatous Involvement of the Central Nervous System.中枢神经系统的骨髓瘤累及
Clin Lymphoma Myeloma Leuk. 2016 Nov;16(11):644-654. doi: 10.1016/j.clml.2016.08.010. Epub 2016 Aug 10.
2
Cutaneous involvement in multiple myeloma: a multi-institutional retrospective study of 53 patients.多发性骨髓瘤的皮肤受累:一项对53例患者的多机构回顾性研究。
Leuk Lymphoma. 2016 Sep;57(9):2071-6. doi: 10.3109/10428194.2015.1128542. Epub 2016 Jan 4.
3
Central nervous system involvement with multiple myeloma: long term survival can be achieved with radiation, intrathecal chemotherapy, and immunomodulatory agents.多发性骨髓瘤累及中枢神经系统:通过放疗、鞘内化疗和免疫调节剂可实现长期生存。
Br J Haematol. 2013 Aug;162(4):483-8. doi: 10.1111/bjh.12414. Epub 2013 Jun 15.