Nakamura Takumi, Kawarabayashi Takeshi, Seino Yusuke, Hirohata Mie, Nakahata Naoko, Narita Sakiko, Itoh Ken, Nakaji Shigeyuki, Shoji Mikio
Department of Neurology Hrosaki University Graduate School of Medicine 5 Zaifu-cho Hirosaki 037-8562 Japan.
Department of Stress Response Science Hirosaki University Graduate School of Medicine 5 Zaifu-cho Hirosaki 037-8562 Japan.
Ann Clin Transl Neurol. 2018 Sep 7;5(10):1184-1191. doi: 10.1002/acn3.635. eCollection 2018 Oct.
The aim of this study was to confirm determinative factors for plasma A and its association with cognitive function.
Fasting plasma A40 and A42 levels were measured by ELISA in 1019 participants in the Iwaki Health Promotion Project. The relationships between plasma A and health-related items, including physical characteristics, cognitive function tests, blood chemistry, and genotype were analyzed.
The plasma levels of A40 and A42, and A40/42 ratio were found to significantly increase with aging. The age-dependent increase in A42 level was significantly suppressed by . Renal function was an associated factor for the plasma A40 level. The plasma A42 level and A40/42 ratio correlated with cognitive function.
Age and are major determinative factors of plasma levels of A42 and the A40/42 ratio. These factors are critical adjustment factors for the usage of plasma A as a biomarker of central nervous system amyloidosis.
本研究旨在确定血浆A的决定性因素及其与认知功能的关联。
在磐城健康促进项目的1019名参与者中，采用酶联免疫吸附测定法（ELISA）测量空腹血浆A40和A42水平。分析血浆A与健康相关指标之间的关系，包括身体特征、认知功能测试、血液化学指标和基因型。
发现血浆A40和A42水平以及A40/42比值随年龄显著升高。A42水平随年龄的升高受到显著抑制。肾功能是血浆A40水平的相关因素。血浆A42水平和A40/42比值与认知功能相关。
年龄和[此处原文缺失具体内容]是血浆A42水平和A40/42比值的主要决定性因素。这些因素是将血浆A用作中枢神经系统淀粉样变性生物标志物时的关键调节因素。
