TGF-β 信号通路介导的去泛素化酶。
TGF-β signaling pathway mediated by deubiquitinating enzymes.
机构信息
Department of Biomedical Science, CHA University, 335 Pangyo-Ro, Bundang-Gu, Seongnam, Gyeonggi, 13488, Republic of Korea.
出版信息
Cell Mol Life Sci. 2019 Feb;76(4):653-665. doi: 10.1007/s00018-018-2949-y. Epub 2018 Oct 22.
Abstract
Ubiquitination is a reversible cellular process mediated by ubiquitin-conjugating enzymes, whereas deubiquitinating enzymes (DUBs) detach the covalently conjugated ubiquitin from target substrates to counter ubiquitination. DUBs play a crucial role in regulating various signal transduction pathways and biological processes including apoptosis, cell proliferation, DNA damage repair, metastasis, differentiation, etc. Since the transforming growth factor-β (TGF-β) signaling pathway participates in various cellular functions such as inflammation, metastasis and embryogenesis, aberrant regulation of TGF-β signaling induces abnormal cellular functions resulting in numerous diseases. This review focuses on DUBs regulating the TGF-β signaling pathway. We discuss the molecular mechanisms of DUBs involved in TGF-β signaling pathway, and biological and therapeutic implications for various diseases.
摘要
泛素化是一种由泛素连接酶介导的可逆细胞过程，而去泛素化酶（DUBs）则将共价连接的泛素从靶底物上脱离，以抵消泛素化。DUBs 在调节各种信号转导途径和生物过程中发挥着关键作用，包括细胞凋亡、细胞增殖、DNA 损伤修复、转移、分化等。由于转化生长因子-β（TGF-β）信号通路参与炎症、转移和胚胎发生等多种细胞功能，TGF-β信号通路的异常调节导致异常的细胞功能，从而导致许多疾病。本综述重点介绍了 DUBs 对 TGF-β信号通路的调节。我们讨论了参与 TGF-β信号通路的 DUBs 的分子机制，以及它们在各种疾病中的生物学和治疗意义。
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