Centre for Oral Immunobiology & Regenerative Medicine and Centre for Oral Clinical Research, Institute of Dentistry, Bart's and the London School of Medicine and Dentistry, Queen Mary University of London (QMUL), Turner Street, London, E1 2AD, UK.
Department of Clinical and Experimental Medicine, Ospedale Cannizzaro, University of Catania, Catania, Italy.
Clin Oral Investig. 2019 Jun;23(6):2695-2703. doi: 10.1007/s00784-018-2667-8. Epub 2018 Oct 22.
The presence of periodontal disease (PD) in subjects affected by the metabolic syndrome (MetS) may affect their risk of developing cardiovascular disease. The aim of this cross-sectional study was to investigate the systemic impact of PD in MetS, by assessing measures of sub-clinical atherosclerosis and left ventricular mass and geometry.
A total of 103 patients undergoing treatment for MetS were examined for confirmation of diagnosis, blood sampling, and measures of pulse wave velocity (PWV), carotid intima-media thickness (c-IMT), left ventricular mass index (LVM), and relative wall thickness (RWT). All subjects underwent a detailed dental assessment, including measurements of DMFT (decayed-missing-filled teeth) and periodontal parameters.
Ten patients (10%) were diagnosed with healthy-mild periodontitis, 38 patients (37%) were diagnosed in the moderate periodontitis group, and 55 (53%) had severe periodontitis. A total of 37% of subjects were affected by dental caries. Linear regression analysis revealed that patients with severe PD had increased average ventricular RWT (adjusted p = 0.032). Average full mouth probing pocket depth (PPD) was also associated with RWT (adjusted p = 0.006). No associations between PD and c-IMT, PWV, and LVM were detected after adjusted analyses.
This study suggests that periodontitis may be associated with concentric left ventricular remodeling, a predictive index of cardiovascular events.
The presence of periodontitis in patients with MetS might have an effect on left ventricular geometry. These findings stress the importance of prevention, diagnosis, and management of periodontitis in patients with MetS.
NCT03297749.
患有代谢综合征（MetS）的患者中存在牙周病（PD）可能会影响他们患心血管疾病的风险。本横断面研究的目的是通过评估亚临床动脉粥样硬化和左心室质量和几何形状的指标来研究 PD 在 MetS 中的系统影响。
共检查了 103 名接受 MetS 治疗的患者以确认诊断、采血，并测量脉搏波速度（PWV）、颈动脉内膜中层厚度（c-IMT）、左心室质量指数（LVM）和相对壁厚度（RWT）。所有患者均接受了详细的牙科评估，包括 DMFT（龋齿缺失填充牙）和牙周参数的测量。
10 名患者（10%）被诊断为轻度健康性牙周炎，38 名患者（37%）被诊断为中度牙周炎，55 名患者（53%）患有严重牙周炎。共有 37%的患者患有龋齿。线性回归分析显示，严重 PD 患者的平均心室 RWT 增加（调整后 p=0.032）。平均全口探诊袋深度（PPD）也与 RWT 相关（调整后 p=0.006）。调整后分析未发现 PD 与 c-IMT、PWV 和 LVM 之间存在关联。
本研究表明，牙周炎可能与心血管事件的预测指标——同心性左心室重构有关。
MetS 患者中存在牙周炎可能会影响左心室几何形状。这些发现强调了在 MetS 患者中预防、诊断和管理牙周炎的重要性。
NCT03297749。
