Sarda Trupti, Rathod Surekha, Kolte Abhay, Bodhare Girish, Modak Anil
Department of Periodontics and Implantology, VSPM Dental College and Research Centre, Nagpur, Maharashtra, India.
Department of Medicine, NKP Salve Institute of Medical Sciences, Nagpur, Maharashtra, India.
Contemp Clin Dent. 2016 Jul-Sep;7(3):343-8. doi: 10.4103/0976-237X.188559.
Chronic periodontitis, an inflammatory disease, is closely related to certain systemic conditions such as cardiovascular diseases, obesity, and Type 2 diabetes mellitus. These conditions, occurring as comorbidities, synergically affect periodontal tissues.
This study aims to examine whether chronic gingivitis and chronic generalized severe periodontitis in patients with Type 2 diabetes mellitus are associated with increased left ventricular mass (LVM).
A total of 45 patients affected with Type 2 diabetes mellitus were recruited and divided into three groups with 15 patients each according to their periodontal status: Group I consisting of healthy individuals, Group II consisting of chronic gingivitis, and Group III consisting of chronic generalized severe periodontitis. They were assessed clinically, biochemically, and echocardiographically. LVM was calculated according to Devereux formula and was indexed to height.
The differences in the means for LVM and LVM index (LVMI) were statistically significant in three groups with a P = 0.006 and 0.014, respectively. After adjusting for the confounders, the mean values of LVM in Group I, II, and III were 149.35 ± 35.51 g, 147.95 ± 31.59 g, and 156.36 ± 36.57 g, respectively and for LVMI, the mean values were 43.61 ± 12.16 g/m(2.7) (Group I), 47.12 ± 10.84 g/m(2.7) (Group II), and 46.34 ± 12.55 g/m(2.7) (Group III).
A positive association between chronic generalized severe periodontitis and increased LVM in Type 2 DM patients was observed, suggesting the role of periodontal disease in the left ventricular hypertrophy.
慢性牙周炎是一种炎症性疾病，与某些全身性疾病密切相关，如心血管疾病、肥胖症和2型糖尿病。这些作为合并症出现的疾病会协同影响牙周组织。
本研究旨在探讨2型糖尿病患者的慢性牙龈炎和慢性广泛性重度牙周炎是否与左心室质量（LVM）增加有关。
共招募了45名2型糖尿病患者，并根据其牙周状况分为三组，每组15人：第一组为健康个体，第二组为慢性牙龈炎患者，第三组为慢性广泛性重度牙周炎患者。对他们进行了临床、生化和超声心动图评估。LVM根据Devereux公式计算，并根据身高进行指数化。
三组的LVM和LVM指数（LVMI）平均值差异具有统计学意义，P值分别为0.006和0.014。在调整混杂因素后，第一组、第二组和第三组的LVM平均值分别为149.35±35.51g、147.95±31.59g和156.36±36.57g，LVMI的平均值分别为43.61±12.16g/m(2.7)（第一组）、47.12±10.84g/m(2.7)（第二组）和46.34±12.55g/m(2.7)（第三组）。
观察到2型糖尿病患者的慢性广泛性重度牙周炎与LVM增加之间存在正相关，提示牙周疾病在左心室肥厚中的作用。
