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巴西不同年龄段人群通过肉类摄入暴露于总砷和无机砷的风险:概率评估。

Risk of exposure to total and inorganic arsenic by meat intake among different age groups from Brazil: a probabilistic assessment.

机构信息

Laboratório de Ciências Ambientais, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Rio de Janeiro, RJ, 28013-602, Brazil.

出版信息

Environ Sci Pollut Res Int. 2018 Dec;25(35):35471-35478. doi: 10.1007/s11356-018-3512-y. Epub 2018 Oct 22.

Abstract

Beef and poultry as well as cattle and chicken livers are staple food items for Brazilian population, and previous studies had detected arsenic levels in these foods. This study aims to evaluate the risk of exposure to total and inorganic arsenic by meat intake in three age groups from Brazil (11-16, 16-21, and > 21 years). Our hypotheses are (i) that there is differences in the risk of exposure between age groups and (ii) the older individuals (> 21 years) are under higher risk. To test these hypotheses, we calculated the probabilistic estimated daily intake of total As (TAs) from poultry, beef, cattle liver, and chicken liver, and the probabilistic estimated incremental lifetime skin, bladder, and lung cancer risk (ILCR) associated with inorganic As ingestion from poultry only. TAs and ILCR from poultry differed among groups which confirm the first hypothesis. However, TAs and ILCR results cannot support the second hypothesis. Even though the age groups are under a low risk of exposure to As by meat intake, the results indicate that bladder/lung cancer risk (from poultry intake) slightly exceeds the safe limits in the older population.

摘要

牛肉、禽肉以及牛、鸡的肝脏是巴西民众的主食,先前的研究已经检测到这些食物中的砷含量。本研究旨在评估巴西三个年龄段(11-16 岁、16-21 岁和>21 岁)人群通过肉类摄入总砷和无机砷的暴露风险。我们的假设是:(i)不同年龄组之间的暴露风险存在差异,(ii)年龄较大的(>21 岁)人群面临更高的风险。为了验证这些假设,我们计算了来自禽肉、牛肉、牛肝和鸡肝的总砷(TAs)和无机砷摄入相关的膀胱癌、肺癌概率性终身增量风险(ILCR)的概率估计日摄入量。禽肉的 TAs 和 ILCR 在不同组之间存在差异,这证实了第一个假设。然而,TAs 和 ILCR 的结果并不能支持第二个假设。尽管各年龄组通过肉类摄入砷的暴露风险较低,但结果表明,膀胱癌/肺癌风险(来自禽肉摄入)在老年人群中略高于安全限值。

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