功能性T淋巴细胞是鼠逆转录病毒诱导的免疫缺陷疾病（MAIDS）所必需的。
Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS).
作者信息
Mosier D E, Yetter R A, Morse H C
出版信息
J Exp Med. 1987 Jun 1;165(6):1737-42. doi: 10.1084/jem.165.6.1737.
Abstract
Athymic nu/nu mice were found to be resistant to the immunodeficiency disease and lethality induced in normal mice by the injection of the LP-BM5 mixture of murine retroviruses (LP-BM5 MuLV). Susceptibility to disease induction was reconstituted by injection of nu/nu mice with purified, mature T lymphocytes. The extent of viral replication of both the ecotropic and mink cell focus forming (MCF) components of LP-BM5 MuLV was equivalent in both nu/nu and normal animals. Retrovirally-induced immunodeficiency disease in mice (MAIDS) is thus dependent upon the presence of functional T lymphocytes, and high virus titers in athymic mice have little or no effect on the immune system.
摘要
无胸腺裸鼠被发现对注射鼠逆转录病毒LP - BM5混合物（LP - BM5 MuLV）诱导正常小鼠产生的免疫缺陷疾病和致死性具有抗性。通过给裸鼠注射纯化的成熟T淋巴细胞可恢复其对疾病诱导的易感性。LP - BM5 MuLV的亲嗜性和貂细胞集落形成（MCF）成分的病毒复制程度在裸鼠和正常动物中相当。因此，小鼠中的逆转录病毒诱导免疫缺陷疾病（MAIDS）依赖于功能性T淋巴细胞的存在，且无胸腺小鼠中的高病毒滴度对免疫系统几乎没有影响。
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