促甲状腺激素释放激素可降低经锂预处理的大鼠小脑肌醇含量。

Thyrotropin-releasing hormone reduces myo-inositol content in rat cerebellum pretreated with lithium.

作者信息

Miyamoto Y, Kikkawa R, Hatanaka I, Yasuda H, Terada M, Yamashita M, Shigeta Y

出版信息

J Neurochem. 1987 Jul;49(1):88-91. doi: 10.1111/j.1471-4159.1987.tb03398.x.

DOI:10.1111/j.1471-4159.1987.tb03398.x

Abstract

The effect of thyrotropin-releasing hormone (TRH) and lithium on myo-inositol metabolism has been assessed in rat cerebral cortex, cerebellar cortex, and sciatic nerves. Sprague-Dawley male rats were injected subcutaneously with 10 mEq/kg of LiCl and intraperitoneally with 10 mg/kg of TRH-tartrate, alone or in combination. Either lithium or TRH alone had little effect on the myo-inositol concentration in cerebellar cortex, whereas the combination of lithium and TRH significantly lowered the level. The myo-inositol level of cerebellar cortex reached its nadir (70% of values in untreated control rats) 30 min after addition of TRH and then returned to the control level at 90 min. In cerebral cortex, both lithium alone and lithium plus TRH significantly reduced the myo-inositol level. No effect was seen on the myo-inositol concentration in sciatic nerves with these regimens. These results suggested that the pharmacological dose of TRH activated phosphatidylinositol turnover in rat cerebellar cortex and subsequently reduced the myo-inositol level in the presence of lithium.

摘要

促甲状腺激素释放激素（TRH）和锂对大鼠大脑皮层、小脑皮层及坐骨神经中肌醇代谢的影响已得到评估。将Sprague-Dawley雄性大鼠皮下注射10 mEq/kg的LiCl，并单独或联合腹腔注射10 mg/kg的酒石酸TRH。单独使用锂或TRH对小脑皮层中的肌醇浓度几乎没有影响，而锂与TRH联合使用则显著降低了该水平。添加TRH后30分钟，小脑皮层的肌醇水平降至最低点（未处理对照大鼠值的70%），然后在90分钟时恢复到对照水平。在大脑皮层中，单独使用锂以及锂加TRH均显著降低了肌醇水平。这些给药方案对坐骨神经中的肌醇浓度没有影响。这些结果表明，药理学剂量的TRH在锂存在的情况下激活了大鼠小脑皮层中的磷脂酰肌醇周转，随后降低了肌醇水平。