Kofman O, Belmaker R H
Beer-Sheva Mental Health Center, Ben Gurion University of the Negev, Beer-Sheva, Israel.
Brain Res. 1990 Nov 26;534(1-2):345-7. doi: 10.1016/0006-8993(90)90155-5.
Several biological effects of lithium have been reversed by in vitro myo-inositol. To determine if intracerebroventricular myo-inositol would reverse behavioural effects of lithium, rats were injected with 5 meq/kg lithium chloride or sodium chloride and injected intracranially with myo-inositol (10 mg) or artificial CSF 24 h and 15 min prior to measurement of activity in an automated activity monitor. Myo-inositol alone had no significant effect on behaviour, but significantly reversed suppression of rearing activity by lithium.
体外肌醇可逆转锂的多种生物学效应。为了确定脑室内注射肌醇是否会逆转锂的行为效应，给大鼠注射5 毫当量/千克氯化锂或氯化钠，并在通过自动活动监测仪测量活动前24小时和15分钟，向大鼠颅内注射肌醇（10毫克）或人工脑脊液。单独使用肌醇对行为没有显著影响，但能显著逆转锂对竖毛活动的抑制作用。
