Naumova O V, Kudaeva I V, Masnavieva L B, D'yakovich O A, Belik V P
Med Tr Prom Ekol. 2017(1):10-13.
The article deals with frequency data on polymorphism of candidate genes participating in endothelial dysfunction (EDN1 Lys198Asn, NOS3 T786C, AGT Thrl74Met and AGT Met23SThr) in totality with concentrations of their active substances in individuals exposed to mercury. Findings are changes in levels of nitrogen oxide, endothelin-1, angiotensin II metabolites in examinees including those without cardiovascular diseases. The genetic conditionality is connected with unfavorable genotypes of polymorphic variants - Met235Thr of AGT gene and Lys198Asn of EDNI gene. Changes in levels of biochemical markers of endothelial dysfunction in individuals exposed to mercury indicate serious endothelial function disorders and are not genetically determined processes.
本文探讨了参与内皮功能障碍的候选基因（内皮素-1 Lys198Asn、一氧化氮合酶3 T786C、血管紧张素原Thr174Met和血管紧张素原Met235Thr）多态性的频率数据，以及接触汞的个体中其活性物质的浓度。研究结果显示，受检者（包括无心血管疾病者）体内一氧化氮、内皮素-1、血管紧张素II代谢产物水平发生了变化。遗传条件与多态性变体的不利基因型有关，即血管紧张素原基因的Met235Thr和内皮素-1基因的Lys198Asn。接触汞的个体中内皮功能障碍生化标志物水平的变化表明存在严重的内皮功能紊乱，且并非由遗传决定。
