Boyarintsev V V, Denisenko I A
Med Tr Prom Ekol. 2016(11):1-7.
The study was aimed to compare efficiency of optimized and combined treatment and rehabilitation in post-apoplexy patients, using standard therapy, cytoflavin and COBS-training. The study involved 51 patients in early (n = 25) and late (n = 26) recovery periods after CVA. Reference groups included patients in early (n = 15) and late (n = is) recovery periods, receiving basic therapy. Evaluations included thepatients' complaints change, activity index (Bartel scale), neurologic state (NIHSS scale), static and locomotory disorders intensity (M.E. Tinetti scale), ultrasound dopplerography, MALDI-TOF-TOF mass spectrometry of serum. Implementation of cytoflavin and COBS-training in CVA patients in early recovery period resulted in better life quality, decrease in neurologi deficit, less static and locomotory disorders, increased average blood velocity, RI, PI on ICA siphon and lower average blood velocity, RI, PI on MCA in comparison with reference groups and CVA patients in late recovery period. Findings are molecular groups of cellular apoptosis, autophagy, necroptosis, ER stress in serum -. explanation of additional links of cytoflavin and COBS-training action mechanism in post-apoplexy patients.
该研究旨在比较标准疗法、细胞色素C和COBS训练对中风后患者进行优化及联合治疗与康复的效果。该研究纳入了51例处于脑卒中超早期（n = 25）和恢复期（n = 26）的患者。对照组包括处于超早期（n = 15）和恢复期（n = 16）接受基础治疗的患者。评估内容包括患者的主诉变化、活动指数（Bartel量表）、神经状态（NIHSS量表）、静态和运动障碍强度（M.E. Tinetti量表）、超声多普勒检查、血清基质辅助激光解吸电离飞行时间串联质谱分析。与对照组和处于恢复期的脑卒中患者相比，在超早期对脑卒中患者实施细胞色素C和COBS训练可改善生活质量，减轻神经功能缺损，减少静态和运动障碍，提高颈内动脉虹吸段的平均血流速度、阻力指数、搏动指数，降低大脑中动脉的平均血流速度、阻力指数、搏动指数。研究结果发现血清中存在细胞凋亡、自噬、坏死性凋亡、内质网应激的分子组，这解释了细胞色素C和COBS训练在中风后患者中的作用机制的其他联系。
