Kartashova E A, Romantsov M G, Sarvilina I V
Eksp Klin Farmakol. 2014;77(6):18-23.
The molecular pharmacological effects of cytoflavin in patients with hypertensive encephalopathy (HE) and isolated systolic arterial hypertension (ISAH) have been investigated using the following methods: assessment of complaints, 24-hour arterial pressure monitoring, ultrasound diagnostics including echocardiography, measurement of lipid profiles and coagulograms, and molecular phenotyping by MALDI-TOF/TOF-MS. A combination of cytoflavin administration with standard therapy of HE and ISAH led to the most expressed return development of clinical symptoms, restoration of the hemodynamic, structural, and geometrical parameters of cardiovascular system, and normalization of the indices of lipid profiles and coagulograms in comparison to patients with HE and ISAH, which accepted only standard therapy. Molecular mechanisms of cytoflavin action have been revealed, which include control of the activity of cellular signaling pathways by means of intermolecular interactions. The optimized therapy of HE and ISAH is recommended for clinical application, which assumes a combined use of standard therapy and cytoflavin and provides a geroprotective action upon the cardiovascular system.
已采用以下方法研究了细胞黄素对高血压脑病（HE）和单纯收缩期动脉高血压（ISAH）患者的分子药理作用：评估症状、24小时动脉血压监测、包括超声心动图在内的超声诊断、血脂谱和凝血图测量，以及通过基质辅助激光解吸电离飞行时间串联质谱（MALDI-TOF/TOF-MS）进行分子表型分析。与仅接受标准治疗的HE和ISAH患者相比，细胞黄素给药与HE和ISAH的标准治疗相结合，导致临床症状最明显的恢复，心血管系统的血流动力学、结构和几何参数恢复正常，血脂谱和凝血图指标正常化。已揭示了细胞黄素作用的分子机制，包括通过分子间相互作用控制细胞信号通路的活性。推荐将HE和ISAH的优化治疗用于临床，即标准治疗与细胞黄素联合使用，并对心血管系统具有老年保护作用。
