Chan Shijia, Leow Wei Qiang
Forensic Medicine Division, Health Sciences Authority, 11 Outram Road, Singapore, 169078, Singapore.
Department of Anatomical Pathology, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore.
J Forensic Sci. 2019 May;64(3):925-929. doi: 10.1111/1556-4029.13929. Epub 2018 Oct 23.
Hepatocellular carcinoma (HCC) is a common cancer worldwide with a great potential for metastatic spread. Hepatocellular carcinoma often arises in people with underlying viral hepatitides or liver cirrhosis and may present in various ways including abdominal pain, liver mass, and signs of hepatocellular decompensation. Many tumors may have metastasized to other organs such as the lungs, lymph nodes, bone, and adrenal glands at the time of diagnosis. However, it is uncommon for HCC to present purely due to its metastasis, such as spinal cord compression from vertebral metastasis. Here, an unusual presentation of a sudden cardiovascular collapse due to medullary and cervical cord infarction from compression of the cervical cord is presented. The importance of clinical investigations, the usefulness of postmortem computed tomography scans, and the examination of the cervical spine and cervical cord in people with no obvious cause of death after standard autopsy procedures are emphasized.
肝细胞癌(HCC)是一种全球常见的癌症,具有很高的转移扩散潜力。肝细胞癌常发生于患有潜在病毒性肝炎或肝硬化的人群中,可能以多种方式出现,包括腹痛、肝脏肿块以及肝细胞失代偿的体征。许多肿瘤在诊断时可能已经转移至其他器官,如肺、淋巴结、骨和肾上腺。然而,肝细胞癌纯粹因转移而出现的情况并不常见,例如因椎体转移导致脊髓受压。在此,我们呈现了一例不寻常的病例,即由于颈髓受压导致延髓和颈髓梗死而突然发生心血管衰竭。强调了临床检查的重要性、尸检计算机断层扫描的作用以及在标准尸检程序后对无明显死因者进行颈椎和颈髓检查的重要性。