miRISC 组成决定了靶标在时间和空间上的命运。
miRISC Composition Determines Target Fates in Time and Space.
机构信息
Department of Biology, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
Department of Biology, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
出版信息
Dev Cell. 2018 Oct 22;47(2):142-143. doi: 10.1016/j.devcel.2018.10.009.
Abstract
MicroRNA-mediated gene silencing can occur by either target mRNA degradation or translational repression. In this issue of Developmental Cell, Dallaire et al. (2018) show in C. elegans that tissue-specific composition of the silencing complex, miRISC, plays a major role in determining the fate of target mRNAs.
摘要
microRNA 介导的基因沉默可以通过靶 mRNA 降解或翻译抑制来发生。在本期《发育细胞》中，Dallaire 等人（2018 年）在秀丽隐杆线虫中表明，沉默复合物 miRISC 的组织特异性组成在决定靶 mRNA 的命运方面起着主要作用。
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