Rombold-Bruehl Felicitas, Otte Christian, Renneberg Babette, Hellmann-Regen Julian, Bruch Linda, Wingenfeld Katja, Roepke Stefan
Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Benjamin Franklin, Germany; Department of Psychology, Freie Universität Berlin, Germany.
Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Benjamin Franklin, Germany.
Neurobiol Learn Mem. 2018 Dec;156:45-52. doi: 10.1016/j.nlm.2018.10.010. Epub 2018 Oct 21.
Traumatic events are often followed by memory impairments of key features of the trauma. Stress hormones are involved in emotional memory formation. However, little is known about their influence during trauma on subsequent recognition memory.
A pooled analysis of two double-blind, placebo-controlled studies (N = 175) was performed to assess the influence of the noradrenergic system and the hypothalamus-pituitaryadrenal (HPA) axis on intrusion formation. Participants received either 10 mg yohimbine (stimulating noradrenergic activity), 0.15 mg clonidine (inhibiting noradrenergic activity), or placebo (noradrenergic manipulation study) or 20 mg hydrocortisone or placebo (hydrocortisone manipulation study), each 60 min before watching a distressing film depicting severe sexual and physical violence. After seven days, the participants performed a 24-item forced choice recognition test. Memory was assessed for pre-, peri-, and post-trauma film scenes.
A significant film scene by intervention interaction indicated a differential influence of drug intervention on the number of correct pre-, peri-, and post-trauma film scene memories one week after the distressing film. Post hoc tests revealed that clonidine led to significantly fewer correct peri-trauma film scene memories compared to placebo and, on a trend level, to yohimbine.
Pharmacological inhibition of noradrenaline during a distressing film leads to impaired emotional recognition memory for the peri-trauma film scene.
创伤事件之后往往伴随着对创伤关键特征的记忆障碍。应激激素参与情绪记忆的形成。然而，关于它们在创伤期间对后续识别记忆的影响却知之甚少。
对两项双盲、安慰剂对照研究（N = 175）进行汇总分析，以评估去甲肾上腺素能系统和下丘脑 - 垂体 - 肾上腺（HPA）轴对侵入性记忆形成的影响。参与者在观看一部描绘严重性暴力和身体暴力的痛苦影片前60分钟，分别接受10毫克育亨宾（刺激去甲肾上腺素能活性）、0.15毫克可乐定（抑制去甲肾上腺素能活性）或安慰剂（去甲肾上腺素能操纵研究），或者20毫克氢化可的松或安慰剂（氢化可的松操纵研究）。七天后，参与者进行一项包含24个条目的强制选择识别测试。对创伤前、创伤期间和创伤后影片场景的记忆进行评估。
显著的影片场景与干预交互作用表明，药物干预对痛苦影片一周后创伤前、创伤期间和创伤后影片场景正确记忆数量有不同影响。事后检验显示，与安慰剂相比，可乐定导致创伤期间影片场景的正确记忆显著减少，并且在趋势水平上，与育亨宾相比也是如此。
在观看痛苦影片期间对去甲肾上腺素进行药理学抑制会导致对创伤期间影片场景的情绪识别记忆受损。
