Maslahati Tolou, Glogau Franziska, Galve Gómez Milagros, Buchholz Katharina, Dormann Lisa, Wingenfeld Katja, Otte Christian, Schultebraucks Katharina, Roepke Stefan
Department of Psychiatry and Psychotherapy, Campus Benjamin Franklin (CBF), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Department of Psychiatry, New York University (NYU) Grossman School of Medicine, New York, NY, United States.
Front Psychiatry. 2025 Apr 3;16:1421305. doi: 10.3389/fpsyt.2025.1421305. eCollection 2025.
Traumatic experiences are thought to alter memory acquisition and consolidation. Cognitive models of PTSD suggest that voluntary and involuntary memories after trauma can be independently addressed through interventions. The administration of oxytocin before exposure to a trauma film led to more intrusive (involuntary) memories than placebo. The effect of oxytocin on voluntary memory of the traumatic film, however, remains unclear. The current study aimed to assess whether intranasal oxytocin administration facilitates forced-choice recognition memory after a trauma film paradigm.
MATERIAL & METHODS: We performed a pooled analysis of two randomized, double-blind, placebo-controlled studies (N = 437) to assess the impact of intranasal oxytocin administration on declarative memory. Participants received 24 I.U. of oxytocin, either 40 minutes before a trauma film paradigm or immediately afterward. We applied a forced-choice recognition task seven days after the trauma film paradigm. The task comprised pre-, peri, and post-trauma film scene details.
The administration of oxytocin did not affect recognition performance for any film scene (2, 401) = .49, = .61). Participants remembered significantly more peri-traumatic film details compared to pre- and post-trauma details (, 802) = 103.38, <.001).
Although the exogenous oxytocin administration before a trauma film has been shown to influence the acquisition of intrusive memories, it does not seem to affect the recognition memory of trauma film details. That aligns with cognitive models of PTSD, suggesting that voluntary and involuntary memory after trauma can be independently addressed through experimental interventions.
创伤经历被认为会改变记忆的获取和巩固。创伤后应激障碍的认知模型表明，创伤后的自愿性和非自愿性记忆可以通过干预措施分别加以处理。在观看创伤影片之前给予催产素比给予安慰剂会导致更多侵入性（非自愿性）记忆。然而，催产素对创伤影片的自愿性记忆的影响仍不清楚。本研究旨在评估鼻内给予催产素是否能促进创伤影片范式后的强制选择再认记忆。
我们对两项随机、双盲、安慰剂对照研究（N = 437）进行了汇总分析，以评估鼻内给予催产素对陈述性记忆的影响。参与者在创伤影片范式前40分钟或之后立即接受24国际单位的催产素。在创伤影片范式七天后，我们应用了强制选择再认任务。该任务包括创伤影片前、创伤期间和创伤后的场景细节。
催产素的给予对任何影片场景的再认表现均无影响（F(2, 401) = .49, p = .61）。与创伤前和创伤后的细节相比，参与者对创伤期间影片细节的记忆明显更多（F(2, 802) = 103.38, p <.001）。
尽管在观看创伤影片前给予外源性催产素已被证明会影响侵入性记忆的获取，但它似乎并不影响对创伤影片细节的再认记忆。这与创伤后应激障碍的认知模型一致，表明创伤后的自愿性和非自愿性记忆可以通过实验干预分别加以处理。
