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颅内动脉瘤:诊断监测、当前介入治疗实践及进展

Intracranial Aneurysm: Diagnostic Monitoring, Current Interventional Practices, and Advances.

作者信息

Ellis Jason A, Nossek Erez, Kronenburg Annick, Langer David J, Ortiz Rafael A

机构信息

Department of Neurosurgery, Zucker School of Medicine at Hofstra/Northwell, Lenox Hill Hospital, 130 E 77th Street, 3rd Floor, New York, NY, 10075, USA.

Division of Neurosurgery, Maimonides Medical Center, Brooklyn, NY, USA.

出版信息

Curr Treat Options Cardiovasc Med. 2018 Oct 24;20(12):94. doi: 10.1007/s11936-018-0695-y.

Abstract

PURPOSE OF REVIEW

Cerebral aneurysms are commonly diagnosed incidentally with non-invasive neuro-imaging modalities (i.e., brain MRA and/or head CTA). The first decision to be made in the management of patients with unruptured cerebral aneurysms is to determine if the aneurysm should undergo treatment as any intervention carries a risk of morbidity and mortality.

RECENT FINDINGS

The multiple risk factors that are associated with increased risk of aneurysm rupture should be evaluated (size, shape, and location of aneurysm; history of hypertension and cigarette smoking and family history of cerebral aneurysms). With the advent and rapid evolution of less traumatic neuro-endovascular surgery techniques in the past two decades, many more patients are undergoing treatment of cerebral aneurysms. The neuro-endovascular surgeon has multiple options for the treatment of aneurysms including coiling, with or without balloon/stent assistance, and flow diversion. A number of intrasaccular devices for the neuro-endovascular treatment of cerebral aneurysms are being evaluated. The percentage of patients with cerebral aneurysms treated with craniotomy and clip ligation is decreasing. This is controversial as it has direct impact in neurosurgical training and the aneurysms that are usually recommended for microsurgical clipping are the ones with challenging anatomy that cannot be treated safely with endovascular approaches. The best outcomes are achieved with management by experienced, high-volume practitioners at specialized cerebrovascular treatment centers that consist of individuals with dedicated training in neuro-endovascular surgery as well as individuals trained in open cerebrovascular neurosurgery.

摘要

综述目的

脑动脉瘤通常是在采用非侵入性神经成像方式(即脑部磁共振血管造影和/或头部CT血管造影)时偶然被诊断出来的。对于未破裂脑动脉瘤患者的治疗,首先要做出的决定是确定该动脉瘤是否应接受治疗,因为任何干预都有发病和死亡风险。

最新发现

应评估与动脉瘤破裂风险增加相关的多种危险因素(动脉瘤的大小、形状和位置;高血压病史、吸烟史以及脑动脉瘤家族史)。在过去二十年中,随着创伤性较小的神经血管内手术技术的出现和迅速发展,越来越多的患者正在接受脑动脉瘤治疗。神经血管内外科医生有多种治疗动脉瘤的选择,包括有或没有球囊/支架辅助的弹簧圈栓塞以及血流导向。一些用于脑动脉瘤神经血管内治疗的瘤内装置正在接受评估。接受开颅夹闭治疗的脑动脉瘤患者比例正在下降。这存在争议,因为它对神经外科培训有直接影响,而且通常建议进行显微手术夹闭的动脉瘤是那些解剖结构具有挑战性、无法通过血管内方法安全治疗的动脉瘤。由经验丰富、手术量大的从业者在专门的脑血管治疗中心进行管理可取得最佳效果,这些中心的人员包括经过神经血管内手术专门培训的人员以及接受过开放性脑血管神经外科培训的人员。

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