Mel'nikov M E, Petrovskii E D, Bezmaternykh D D, Kozlova L I, Shtark M B, Savelov A A, Shubina O S, Natarova K A
Research Institute of Molecular Biology and Biophysics, Novosibirsk, Russia.
Novosibirsk National Research State University, Novosibirsk, Russia.
Bull Exp Biol Med. 2018 Oct;165(6):741-745. doi: 10.1007/s10517-018-4255-y. Epub 2018 Oct 23.
fMRI markers of mild depression were revealed using standard emotional test. Patients with mild depression and healthy volunteers were asked to determine gender of subjects in photographs with different emotional expressions (neutral, surprise, disgust, confusion, anger, sadness, fear, and joy). The pattern of response to different emotions was universal in both groups and included the largest clusters in the occipital region, as well as a certain volume in the parietal lobes and posterior lateral frontal cortex. In depression group, a lack of activation in the middle cingulate gyrus (bilaterally) and in the postcentral and inferior parietal gyrus (left) in response to presentation of sad faces. For other emotion, no large clusters of intergroup contrasts significant at p<0.05 with FWE correction were revealed. The response of the middle cingulate gyrus and the left inferior parietal lobe can be considered as a potential diagnostic marker of depressive disorders and as the target for neurofeedback.
使用标准情绪测试揭示了轻度抑郁症的功能磁共振成像（fMRI）标记物。要求轻度抑郁症患者和健康志愿者判断具有不同情绪表达（中性、惊讶、厌恶、困惑、愤怒、悲伤、恐惧和喜悦）的照片中人物的性别。两组对不同情绪的反应模式是普遍的，包括枕叶区域最大的簇，以及顶叶和额叶后外侧的一定体积区域。在抑郁症组中，面对悲伤面孔时，双侧扣带中央回以及左侧中央后回和顶下小叶缺乏激活。对于其他情绪，未发现经家族性错误率（FWE）校正后p<0.05的显著组间差异大簇。扣带中央回和左侧顶下叶的反应可被视为抑郁症的潜在诊断标记物和神经反馈的靶点。
