Department of Cardiovascular Medicine, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
School of Chemistry & Biosciences, University of Bradford, Bradford, BD7 1DP, UK.
Nanomedicine (Lond). 2018 Dec;13(23):3037-3050. doi: 10.2217/nnm-2018-0264. Epub 2018 Oct 24.
In recent years, tremendous progress has been made in the treatment of acute myocardial infarction, but pathological ventricular remodeling often causes survivors to suffer from fatal heart failure. Currently, there is no effective therapy to attenuate ventricular remodeling. Recently, nanoparticle-based drug delivery systems are widely applied in biomedicine especially in cancer and liver fibrosis, owing to its excellent physical, chemical and biological properties. Therefore, the use of nanoparticles as delivery vehicles of small molecules, polypeptides, etc. to improve postinfarct ventricular remodeling is expected. In this review, we summarize the updated researches in this fast-growing area and suggest further works needed.
近年来，急性心肌梗死的治疗取得了巨大进展，但病理性心室重构常常导致幸存者发生致命性心力衰竭。目前，尚无有效的治疗方法来减轻心室重构。最近，基于纳米粒子的药物传递系统由于其优异的物理、化学和生物学特性，在生物医学领域，尤其是在癌症和肝纤维化方面得到了广泛应用。因此，使用纳米粒子作为小分子、多肽等的递送载体来改善梗死后期的心室重构是有前景的。在这篇综述中，我们总结了这一快速发展领域的最新研究，并提出了进一步需要开展的工作。
