Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, St. Lucia Campus, Brisbane, Queensland 4072, Australia; email:
Brain and Mind Centre and Central Clinical School, Sydney Medical School, University of Sydney, New South Wales 2006, Australia.
Annu Rev Pathol. 2019 Jan 24;14:239-261. doi: 10.1146/annurev-pathmechdis-012418-012936. Epub 2018 Oct 24.
The tauopathies constitute a group of diseases that have Tau inclusions in neurons or glia as their common denominator. In this review, we describe the biochemical and histological differences in Tau pathology that are characteristic of the spectrum of frontotemporal lobar degeneration as primary tauopathies and of Alzheimer's disease as a secondary tauopathy, as well as the commonalities and differences between the familial and sporadic forms. Furthermore, we discuss selected advances in transgenic animal models in delineating the different pathomechanisms of Tau.
神经tau 病是以神经元或神经胶质细胞内存在 Tau 包涵体作为共同特征的一组疾病。在这篇综述中，我们描述了 Tau 病理学在神经退行性疾病中的生物化学和组织学差异，这些差异是额颞叶痴呆作为原发性 Tau 病和阿尔茨海默病作为继发性 Tau 病的特征，以及家族性和散发性形式之间的异同。此外，我们还讨论了转基因动物模型在阐明 Tau 不同病理机制方面的一些进展。
