血管紧张素 II 与阿尔茨海默病型心血管衰老。
Angiotensin II- and Alzheimer-Type Cardiovascular Aging.
机构信息
From the Cardiovascular Research Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA.
出版信息
Circ Res. 2018 Aug 31;123(6):651-653. doi: 10.1161/CIRCRESAHA.118.313477.
Abstract
Over the past millennium, great strides have been made in expanding the human life span. Such gains however, have come with the cost of increasing age-related diseases such as Alzheimer’s disease. Slowing “biological” aging therefore may be a way to reduce morbidity and significantly impact the quality of life for the elderly. Enhanced angiotensin II (Ang II) signal transduction has been implicated in premature aging and evidence exists for the prolongation of life through blockade of the Ang II type-1 receptor (ATR). In this Viewpoint article, we will discuss noteworthy similarities between Ang II pathophysiology and Alzheimer’s disease as potential intervention points to promote healthy aging.
摘要
在过去的一千年里，人类的寿命得到了极大的延长。然而，这种进步是有代价的，随着年龄的增长，与年龄相关的疾病（如阿尔茨海默病）也越来越多。因此，减缓“生物”衰老可能是减少发病率和显著提高老年人生活质量的一种方法。增强的血管紧张素 II（Ang II）信号转导与早衰有关，并且有证据表明通过阻断血管紧张素 II 型 1 受体（ATR）可以延长寿命。在这篇观点文章中，我们将讨论 Ang II 病理生理学和阿尔茨海默病之间的显著相似之处，这些相似之处可能是促进健康衰老的潜在干预点。
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