From the Weill Cornell Medicine, Feil Family Brain and Mind Research Institute, New York (C.I.).
Department of Neurology and Epidemiology, Johns Hopkins University, Baltimore, MD (R.F.G.).
Circ Res. 2018 Aug 3;123(4):406-408. doi: 10.1161/CIRCRESAHA.118.313400.
Alzheimer’s disease, the leading cause of cognitive impairment in the elderly, has traditionally been considered a disease of neurons. Structural and function alterations of cerebral blood vessels also occur, but direct evidence of a causal involvement in the pathobiology of the disease has been lacking. This Viewpoint will review new data that may help shed light into the intriguing association between vascular and neurodegenerative pathology.
阿尔茨海默病是导致老年人认知障碍的主要原因，传统上被认为是一种神经元疾病。大脑血管的结构和功能也会发生改变，但直接证据表明其在疾病的病理生物学中起因果作用一直缺乏。本观点将回顾新的数据，这些数据可能有助于阐明血管和神经退行性病理之间令人着迷的关联。
