阿尔茨海默病的脑血管改变。
Cerebrovascular Alterations in Alzheimer Disease.
机构信息
From the Weill Cornell Medicine, Feil Family Brain and Mind Research Institute, New York (C.I.).
Department of Neurology and Epidemiology, Johns Hopkins University, Baltimore, MD (R.F.G.).
出版信息
Circ Res. 2018 Aug 3;123(4):406-408. doi: 10.1161/CIRCRESAHA.118.313400.
Abstract
Alzheimer’s disease, the leading cause of cognitive impairment in the elderly, has traditionally been considered a disease of neurons. Structural and function alterations of cerebral blood vessels also occur, but direct evidence of a causal involvement in the pathobiology of the disease has been lacking. This Viewpoint will review new data that may help shed light into the intriguing association between vascular and neurodegenerative pathology.
摘要
阿尔茨海默病是导致老年人认知障碍的主要原因，传统上被认为是一种神经元疾病。大脑血管的结构和功能也会发生改变，但直接证据表明其在疾病的病理生物学中起因果作用一直缺乏。本观点将回顾新的数据，这些数据可能有助于阐明血管和神经退行性病理之间令人着迷的关联。
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Alzheimers Dement. 2018 Feb;14(2):148-156. doi: 10.1016/j.jalz.2017.07.755. Epub 2017 Sep 30.
2
The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease.神经血管单元的成熟：健康与疾病中神经血管耦合的历程
Neuron. 2017 Sep 27;96(1):17-42. doi: 10.1016/j.neuron.2017.07.030.
3
Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort.社区动脉粥样硬化风险（ARIC）队列研究中中年血管危险因素与25年痴呆症发病的关联
JAMA Neurol. 2017 Oct 1;74(10):1246-1254. doi: 10.1001/jamaneurol.2017.1658.
4
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J Am Geriatr Soc. 2017 Aug;65(8):1836-1841. doi: 10.1111/jgs.14903. Epub 2017 Apr 13.
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