BACE1 inhibition as a therapeutic strategy for Alzheimer's disease.
作者信息
Vassar Robert
机构信息
Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
出版信息
J Sport Health Sci. 2016 Dec;5(4):388-390. doi: 10.1016/j.jshs.2016.10.004. Epub 2016 Oct 21.
Abstract
摘要
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BACE1 inhibition as a therapeutic strategy for Alzheimer's disease.抑制β-分泌酶1作为治疗阿尔茨海默病的一种策略。
J Sport Health Sci. 2016 Dec;5(4):388-390. doi: 10.1016/j.jshs.2016.10.004. Epub 2016 Oct 21.
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BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease.β-分泌酶1的生理功能可能限制其作为阿尔茨海默病治疗靶点的应用。
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BACE1 molecular docking and anti-Alzheimer's disease activities of ginsenosides.β-分泌酶1（BACE1）的分子对接及人参皂苷的抗阿尔茨海默病活性
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MiR-124 acts as a target for Alzheimer's disease by regulating BACE1.微小RNA-124通过调控β-分泌酶1作为阿尔茨海默病的一个靶点。
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Alzheimer's therapy targeting the β-secretase enzyme BACE1: Benefits and potential limitations from the perspective of animal model studies.针对β-分泌酶BACE1的阿尔茨海默病治疗：从动物模型研究角度看其益处与潜在局限性
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Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions.BACE1 是否适合作为阿尔茨海默病治疗的靶点？当前策略和未来方向。
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Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes.斑马鱼中 Bace2 的缺失会影响黑素细胞的迁移，并且与 Bace1 敲除表型不同。
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Functions of the Alzheimer's Disease Protease BACE1 at the Synapse in the Central Nervous System.阿尔茨海默病蛋白酶BACE1在中枢神经系统突触处的功能
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Anti-Alzheimer's disease activity of compounds from the root bark of Morus alba L.桑白皮中化合物的抗阿尔茨海默病活性
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Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS.重新审视外周汇假说：在外周抑制β-分泌酶1（BACE1）的活性并不会改变中枢神经系统中的β-淀粉样蛋白水平。
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Exploration of small molecules as inhibitors of potential BACE1 protein to treat amyloid cerebrovascular disease by employing molecular modeling and simulation approaches.通过分子建模和模拟方法探索小分子作为潜在β-分泌酶1（BACE1）蛋白抑制剂以治疗淀粉样脑血管病。
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Amylin and Secretases in the Pathology and Treatment of Alzheimer's Disease.淀粉样肽和分泌酶在阿尔茨海默病的发病机制和治疗中的作用。
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Glycosaminoglycans from Inhibit the Alzheimer's Disease β Secretase, BACE1.糖胺聚糖抑制阿尔茨海默病β 分泌酶，BACE1。
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Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors.结合虚拟筛选方案和体外评估发现 BACE1 抑制剂。
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Inhibition of BACE1, the β-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from .一种来自……的硫酸软骨素提取物对β-分泌酶1（与阿尔茨海默病相关的β-分泌酶）的抑制作用 。
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A Glycosaminoglycan Extract from Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease.一种糖胺聚糖提取物可抑制 BACE1，BACE1 是阿尔茨海默病相关的 β 分泌酶。
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Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment.用于阿尔茨海默病治疗的β-分泌酶1（BACE1）抑制剂研究亮点
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Physical activity and prevention of Alzheimer's disease.身体活动与阿尔茨海默病的预防
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本文引用的文献
1
BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.BACE2 酶加工 PMEL 以在色素细胞中形成黑素体淀粉样基质。
Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10658-63. doi: 10.1073/pnas.1220748110. Epub 2013 Jun 10.
2
β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects.β-淀粉样前体蛋白（APP）裂解酶 1（BACE1）缺陷小鼠表现出类似 L1（CHL1）功能丧失表型，涉及轴突导向缺陷。
J Biol Chem. 2012 Nov 9;287(46):38408-25. doi: 10.1074/jbc.M112.415505. Epub 2012 Sep 17.
3
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.外泌体蛋白富集鉴定神经元中生理 BACE1 蛋白酶的底物。
EMBO J. 2012 Jun 22;31(14):3157-68. doi: 10.1038/emboj.2012.173.
4
The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo.神经细胞黏附分子 L1 和 CHL1 可被体内 BACE1 蛋白酶切割。
J Biol Chem. 2012 Jul 27;287(31):25927-40. doi: 10.1074/jbc.M112.377465. Epub 2012 Jun 12.
5
Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass.Bace2 是一种β细胞丰富的蛋白酶，可调节胰腺β细胞的功能和数量。
Cell Metab. 2011 Sep 7;14(3):365-77. doi: 10.1016/j.cmet.2011.06.018.
6
Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice.BACE1的部分降低对APP转基因小鼠的阿尔茨海默斑块和突触病理具有显著影响。
J Biol Chem. 2007 Sep 7;282(36):26326-34. doi: 10.1074/jbc.M611687200. Epub 2007 Jul 6.
7
BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice.β-分泌酶1基因缺失可预防5XFAD APP/PS1转基因小鼠的神经元丢失和记忆缺陷。
Neurobiol Dis. 2007 Apr;26(1):134-45. doi: 10.1016/j.nbd.2006.12.008. Epub 2006 Dec 20.
8
BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.β-分泌酶1（BACE1）是大脑对β-淀粉样蛋白生成产生选择性易损性的主要决定因素，对认知、情感和突触功能至关重要。
J Neurosci. 2005 Dec 14;25(50):11693-709. doi: 10.1523/JNEUROSCI.2766-05.2005.
9
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice.BACE1和BACE2基因敲除小鼠的表型和生化分析。
J Biol Chem. 2005 Sep 2;280(35):30797-806. doi: 10.1074/jbc.M505249200. Epub 2005 Jun 29.
10
BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease.β-分泌酶1（BACE1）缺乏可挽救阿尔茨海默病小鼠模型中的记忆缺陷和胆碱能功能障碍。
Neuron. 2004 Jan 8;41(1):27-33. doi: 10.1016/s0896-6273(03)00810-9.
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