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BACE1 inhibition as a therapeutic strategy for Alzheimer's disease.

作者信息

Vassar Robert

机构信息

Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

出版信息

J Sport Health Sci. 2016 Dec;5(4):388-390. doi: 10.1016/j.jshs.2016.10.004. Epub 2016 Oct 21.

DOI:10.1016/j.jshs.2016.10.004
PMID:30356583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6188930/
Abstract
摘要

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BACE1 inhibition as a therapeutic strategy for Alzheimer's disease.抑制β-分泌酶1作为治疗阿尔茨海默病的一种策略。
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2
BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease.β-分泌酶1的生理功能可能限制其作为阿尔茨海默病治疗靶点的应用。
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BACE1 molecular docking and anti-Alzheimer's disease activities of ginsenosides.β-分泌酶1（BACE1）的分子对接及人参皂苷的抗阿尔茨海默病活性
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Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions.BACE1 是否适合作为阿尔茨海默病治疗的靶点？当前策略和未来方向。
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本文引用的文献

1
BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.BACE2 酶加工 PMEL 以在色素细胞中形成黑素体淀粉样基质。
Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10658-63. doi: 10.1073/pnas.1220748110. Epub 2013 Jun 10.
2
β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects.β-淀粉样前体蛋白（APP）裂解酶 1（BACE1）缺陷小鼠表现出类似 L1（CHL1）功能丧失表型，涉及轴突导向缺陷。
J Biol Chem. 2012 Nov 9;287(46):38408-25. doi: 10.1074/jbc.M112.415505. Epub 2012 Sep 17.
3
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.外泌体蛋白富集鉴定神经元中生理 BACE1 蛋白酶的底物。
EMBO J. 2012 Jun 22;31(14):3157-68. doi: 10.1038/emboj.2012.173.
4
The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo.神经细胞黏附分子 L1 和 CHL1 可被体内 BACE1 蛋白酶切割。
J Biol Chem. 2012 Jul 27;287(31):25927-40. doi: 10.1074/jbc.M112.377465. Epub 2012 Jun 12.
5
Bace2 is a β cell-enriched protease that regulates pancreatic β cell function and mass.Bace2 是一种β细胞丰富的蛋白酶，可调节胰腺β细胞的功能和数量。
Cell Metab. 2011 Sep 7;14(3):365-77. doi: 10.1016/j.cmet.2011.06.018.
6
Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice.BACE1的部分降低对APP转基因小鼠的阿尔茨海默斑块和突触病理具有显著影响。
J Biol Chem. 2007 Sep 7;282(36):26326-34. doi: 10.1074/jbc.M611687200. Epub 2007 Jul 6.
7
BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice.β-分泌酶1基因缺失可预防5XFAD APP/PS1转基因小鼠的神经元丢失和记忆缺陷。
Neurobiol Dis. 2007 Apr;26(1):134-45. doi: 10.1016/j.nbd.2006.12.008. Epub 2006 Dec 20.
8
BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.β-分泌酶1（BACE1）是大脑对β-淀粉样蛋白生成产生选择性易损性的主要决定因素，对认知、情感和突触功能至关重要。
J Neurosci. 2005 Dec 14;25(50):11693-709. doi: 10.1523/JNEUROSCI.2766-05.2005.
9
Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice.BACE1和BACE2基因敲除小鼠的表型和生化分析。
J Biol Chem. 2005 Sep 2;280(35):30797-806. doi: 10.1074/jbc.M505249200. Epub 2005 Jun 29.
10
BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease.β-分泌酶1（BACE1）缺乏可挽救阿尔茨海默病小鼠模型中的记忆缺陷和胆碱能功能障碍。
Neuron. 2004 Jan 8;41(1):27-33. doi: 10.1016/s0896-6273(03)00810-9.